How to Diagnose and Phenotype Asthma

被引：33

作者：

Nair, Parameswaran

Dasgupta, Angira

Brightling, Christopher E. ^{[1
]}

Chung, Kian Fan ^{[2
,3
]}

机构：

[1] Univ Leicester, Glenfield Hosp, Infect & Inflammat Inst, Leicester LE3 9QP, Leics, England

[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London 5W3 6NP, England

[3] Royal Brompton Hosp, NIHR Biomed Res Unit, London SW3 6NP, England

来源：

CLINICS IN CHEST MEDICINE | 2012年 / 33卷 / 03期

关键词：

Asthma; Phenotyping; Inflammation; EXHALED NITRIC-OXIDE; SPUTUM CELL COUNTS; AIRWAY WALL THICKNESS; RELATIVE CORTICOSTEROID INSENSITIVITY; BLOOD MONONUCLEAR-CELLS; PEAK EXPIRATORY FLOW; COMPUTED-TOMOGRAPHY; LUNG-FUNCTION; NEUTROPHILIC INFLAMMATION; BRONCHIAL HYPERRESPONSIVENESS;

D O I：

10.1016/j.ccm.2012.05.003

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Asthma has been described as a chronic disease of the airways characterized by variable airflow obstruction, airway hyperresponsiveness, and airway inflammation. This review discusses the diagnosis and phenotyping of asthma, with a special emphasis on phenotyping based on the nature of cellular inflammation and radiological imaging and how this could be used to direct the treatment of asthma and, in the future, to apply specifically directed therapies to specific phenotypes.

引用

页码：445 / +

页数：15

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