One-pot Synthesis of Highly Functionalized Tetrahydropyridines: A Camphoresulfonic Acid Catalyzed Multicomponent Reaction

被引：40

作者：

Bharti, Ruchi ^{[1
]}

Parvin, Tasneem ^{[1
]}

机构：

[1] Natl Inst Technol Patna, Dept Chem, Patna 800005, Bihar, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 06期

关键词：

DIVERSITY-ORIENTED SYNTHESIS; FACILE ACCESS; PIPERIDINE; ATOM;

D O I：

10.1002/jhet.2268

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and straight forward solvent free method for the synthesis of a series of highly functionalized tetrahydropyridine derivatives has been achieved via multicomponent reaction of aromatic aldehydes, various amines, and -keto esters at room temperature using readily available (+/-)-camphor-10-sulfonic acid as an organocatalyst. The current protocol offers an atom economic and environmentally benign method for the synthesis of the title compounds under solvent free conditions in good yields with high substrate scope and avoids column chromatographic purification.

引用

页码：1806 / 1811

页数：6

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