Adult celiac disease: clinical experience

被引:0
作者
Mancilla, C
Madrid, AM
Valenzuela, J
Morales, A
Hurtado, C
Smok, G
Ledezma, R
Castillo, I
Rivas, M
Brahm, J [1 ]
机构
[1] Univ Chile, Hosp Clin, Dept Med, Secc Gastroenterol, Santiago, Chile
[2] Univ Chile, Hosp Clin, Dept Anat Patol, Santiago, Chile
[3] Univ Chile, Fac Med, Santiago, Chile
关键词
celiac disease; gluten; transglutaminase;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The prevalence of celiac disease (CD) is unknown in Chile. We have recently noted a rise in the number of cases diagnosed among adults. Aim: To describe the clinical characteristics of a group of adult celiac patients. Patients and methods: Clinical data of patients older than 15 years with positive antitransglutaminase or antiendomysial autoantibodies and a duodenal biopsy characteristic of CD were retrospectively reviewed. Age at diagnosis, symptoms and signs and laboratory. endoscopic and histological findings, were analyzed. Results: Thirty seven patients (28 women), were studied. Median age at diagnosis was 41 years (range 15-69). Main symptoms and signs were diarrhea (78%), weight loss (38%) and abdominal pain (38%). Anemia was found in 49% elevation of ESR in 57%, elevation of alkaline phosphatases in 54%, elevation of aspartate aminotransferase in 38% and a rise in alanine aminotransferase in 27%. Antiendomysial antibodies were positive in 17/22 (77%) and antitransglutamirnase in 19/22 (86%)patients. Endoscopic findings were suggestive Of CD in 4 No of cases and duodenal biopsy showed intestinal villi atrophy in 34 (92%) patients. The three patients with normal histology had positive serology and a good response to gluten free diet. Conclusions: CD should be considered in the differential diagnosis of patients with unespecific digestive symptons, even when they;present late in adult life. Serologic markers are a good diagnostic tool. A normal duodenal pathology does not exclude the diagnosis, if other diagnostic features are present.
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页码:1317 / 1321
页数:5
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