Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose

被引：1

作者：

Roine, Antti ^{[1
]}

Tolvanen, Mikko

Sipilainen, Miki

Kumpulainen, Pekka ^{[2
]}

Helenius, Merja A. ^{[3
]}

Lehtimaki, Terho ^{[4
]}

Vepsalainen, Jouko ^{[5
]}

Keinanen, Tuomo A. ^{[5
]}

Hakkinen, Merja R. ^{[5
]}

Koskimaki, Juha ^{[6
]}

Veskimae, Erik ^{[6
]}

Tuokko, Antti

Visakorpi, Tapio ^{[3
]}

Tammela, Teuvo L. ^{[1
,6
]}

Sioris, Thanos ^{[7
]}

Paavonen, Timo ^{[8
]}

Lekkala, Jukka ^{[2
]}

Helle, Hannu ^{[9
]}

Oksala, Niku K. J. ^{[1
,10
]}

机构：

[1] Univ Tampere, Sch Med, Dept Surg, FIN-33101 Tampere, Finland

[2] Tampere Univ Technol, Dept Automat Sci & Engn, FIN-33101 Tampere, Finland

[3] Univ Tampere, Inst Biomed Technol & BioMediTech, FIN-33101 Tampere, Finland

[4] Tampere Univ Hosp, Dept Clin Chem, Fimlab Labs, FIN-33521 Tampere, Finland

[5] Univ Eastern Finland, Bioctr Kuopio, Sch Pharm, Kuopio, Finland

[6] Tampere Univ Hosp, Dept Urol, Tampere, Finland

[7] Tampere Univ Hosp, Ctr Heart, Tampere, Finland

[8] Univ Tampere, Sch Med, Dept Pathol, FIN-33101 Tampere, Finland

[9] VTT Tech Res Ctr Finland, Tampere, Finland

[10] Tampere Univ Hosp, Dept Vasc Surg, Tampere, Finland

来源：

FUTURE ONCOLOGY | 2012年 / 8卷 / 09期

关键词：

cell lines; electronic nose; machine olfaction; olfactory detection; prostate cancer; volatile organic compounds; VOLATILE ORGANIC-COMPOUNDS; CANINE SCENT DETECTION; LUNG-CANCER; IN-VITRO; OLFACTORY DETECTION; GAS SENSOR; MELANOMA; BREATH; ARRAY; DOGS;

D O I：

10.2217/FON.12.93

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To determine whether an electronic nose can differentiate cultured nonmalignant and malignant prostatic cells from each other and whether the smell print is secreted to the surrounding medium. Materials & methods: Prostatic nonmalignant (EP-156T and controls) and malignant (LNCaP) cell lines, as well as conditioned and unconditioned media, were collected. The smell prints of the samples were analyzed by a ChemPro (R) 100 electronic nose device. The data were normalized and dimension reduction was conducted. The samples were classified and misclassification rates were calculated. Results: The electronic nose differentiated the nonmalignant and malignant cell lines from each other, achieving misclassification rates of 2.9-3.6%. Cells did not differ from the conditioned medium but differed from the unconditioned medium (misclassification rates: 0.0-25.6%). Conclusion: Malignant and nonmalignant prostatic cell lines have distinct smell prints. Prostatic cancer cells seem to modify the smell print of their medium.

引用

页码：1157 / 1165

页数：9

共 21 条

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