Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration

被引：30

作者：

Kwon, Yungeun ^{[1
]}

Wang, Qiu ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 11期

基金：

美国国家卫生研究院;

关键词：

INTRAMOLECULAR AMINOCYANATION; DIAMINATION; PALLADIUM; AMINOHYDROXYLATION; TRANSFORMATION; OLEFINS;

D O I：

10.1021/acs.orglett.0c01217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed aminocyanation of alkenes has been achieved through distal cyano migration using O-benzoylhydroxylamines and N-fluorobenzenesulfonimides. This method offers a rapid approach to generate diverse beta-amino and beta-sulfonimido nitriles. These reactions feature mild conditions, tolerance of sensitive functional groups, and excellent regioselectivity. Mechanistic studies suggest that these transformations are initiated by a copper-catalyzed amination step followed by a cyano migration step.

引用

收藏

页码：4141 / 4145

页数：5

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