Involvement of immune cells in the pathogenesis of endometriosis

被引:139
作者
Izumi, Gentaro [1 ]
Koga, Kaori [1 ]
Takamura, Masashi [1 ]
Makabe, Tomoko [1 ]
Satake, Erina [1 ]
Takeuchi, Arisa [1 ]
Taguchi, Ayumi [1 ]
Urata, Yoko [1 ]
Fujii, Tomoyuki [1 ]
Osuga, Yutaka [1 ]
机构
[1] Univ Tokyo, Dept Obstet & Gynecol, Tokyo, Japan
关键词
dendritic cells; endometriosis; lymphocytes; macrophages; neutrophils; NATURAL-KILLER-CELLS; ENDOTHELIAL GROWTH-FACTOR; PERITONEAL-FLUID MACROPHAGES; TO-LYMPHOCYTE RATIO; STROMAL CELLS; DENDRITIC CELLS; MURINE MODEL; PERIPHERAL-BLOOD; NK CELLS; REGULATED-ALPHA;
D O I
10.1111/jog.13559
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation; however, retrograde menstruation occurs in almost all women and other factors are required for the establishment of endometriosis, such as cell survival, cell invasion, angiogenesis, and cell growth. Immune factors in the local environment may, therefore, contribute to the formation and progression of endometriosis. Current evidence supports the involvement of immune cells in the pathogenesis of endometriosis. Peritoneal neutrophils and macrophages secrete biochemical factors that help endometriotic cell growth and invasion, and angiogenesis. Peritoneal macrophages and NK cells in endometriosis have limited capability of eliminating endometrial cells in the peritoneal cavity. An imbalance of T cell subsets leads to aberrant cytokine secretions and inflammation that results in the growth of endometriosis lesions. It is still uncertain whether these immune cells have a role in the initial cause and/or stimulate actions that enhance disease; however, in either case, modulating the actions of these cells may prevent initiation or disease progression. Further studies are needed to deepen the understanding of the pathology of endometriosis and to develop novel management approaches of benefit to women suffering from this disease.
引用
收藏
页码:191 / 198
页数:8
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