pH-Induced reorientation of cytochrome c on silica nanoparticles

被引：28

作者：

Meissner, Jens ^{[1
]}

Wu, Yao ^{[2
]}

Jestin, Jacques ^{[3
]}

Shelton, William A. ^{[2
,4
]}

Findenegg, Gerhard H. ^{[1
]}

Bharti, Bhuvnesh ^{[2
]}

机构：

[1] Tech Univ Berlin, Stranski Lab Phys & Theoret Chem, D-10623 Berlin, Germany

[2] Louisiana State Univ, Cain Dept Chem Engn, Baton Rouge, LA 70803 USA

[3] CEA Saclay, Lab Loen Brillouin, F-91191 Gif Sur Yvette, France

[4] Louisiana State Univ, Ctr Computat & Technol, Baton Rouge, LA 70803 USA

来源：

SOFT MATTER | 2019年 / 15卷 / 03期

关键词：

PROTEIN ADSORPTION; GOLD NANOPARTICLES; ORIENTATION; STABILIZATION; LYSOZYME; BINDING; HALOS; PROBE; SIZE;

D O I：

10.1039/c8sm01909f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied in a wide pH range by combining small-angle neutron scattering, adsorption measurements, and molecular dynamics simulations. The results indicate a reorientation of the ellipsoidal protein from head-on to side-on as the pH is increased. This is attributed to changes in the surface charge distribution of both the protein and the nanoparticles.

引用

页码：350 / 354

页数：5

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