Intestinal microbiota, pathophysiology and translation to probiotic use in patients with irritable bowel syndrome

被引：0

作者：

Almansa, Cristina ^{[1
]}

Agrawal, Anurag ^{[2
]}

Houghton, Lesley A. ^{[1
,3
]}

机构：

[1] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Jacksonville, FL 32224 USA

[2] Doncaster Royal Infirm, Dept Gastroenterol, Doncaster DN2 5LT, England

[3] Univ Manchester, Manchester, Lancs, England

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2012年 / 6卷 / 03期

关键词：

immune system; inflammation; irritable bowel syndrome; motility; probiotics; visceral sensitivity; RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; INDUCED VISCERAL HYPERSENSITIVITY; RHAMNOSUS-STRAIN-GG; DOUBLE-BLIND; CLINICAL-TRIAL; LACTOBACILLUS-REUTERI; MAST-CELL; GERM-FREE; GASTROINTESTINAL MICROBIOTA;

D O I：

10.1586/EGH.12.9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Probiotic agents have received growing attention in recent years as an alternative therapeutic tool in the management of irritable bowel syndrome. In this article, we will discuss the rationale that support this indication, including the role of intestinal microbiota in gastrointestinal function in both human and animal models, potential links between an impaired microbiota imbalance and the psycho-immunopathophysiology of irritable bowel syndrome, and the results of the available clinical trials to date.

引用

页码：383 / 398

页数：16

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