Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma

被引：13
|
作者：
Kashiwazaki, Haruhiko [1 ]
Hassan, Nur Mohammad Monsur [1 ]
Hamada, Jun-ichi [2 ]
Moriuchi, Tetsuya [2 ]
Yamazaki, Yutaka [3 ]
Tei, Kanchu [4 ]
Totsuka, Yasunori [4 ]
Inoue, Nobuo [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Hlth Sci, Kita Ku, Sapporo, Hokkaido 0608586, Japan
[2] Hokkaido Univ, Inst Med Genet, Div Canc Related Genes, Sapporo, Hokkaido, Japan
[3] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Pathobiol Sci, Sapporo, Hokkaido, Japan
[4] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Pathobiol Sci, Sapporo, Hokkaido, Japan
来源：
ODONTOLOGY | 2008年 / 96卷 / 01期
关键词：
oral squamous cell carcinoma; lymph node metastasis; cDNA array; gene expression profiling; biomarkers;
D O I：
10.1007/s10266-008-0084-1
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.
引用
收藏
页码：38 / 43
页数：6
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