The phosphorylation cascade hypothesis of Alzheimer's disease

被引：7
|
作者：
Brinkmalm, Gunnar [1 ,2 ]
Zetterberg, Henrik [1 ,2 ,3 ,4 ]
机构：
[1] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
[2] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
[3] UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, London, England
[4] UCL, UK Dementia Res Inst, London, England
来源：
NATURE AGING | 2021年 / 1卷 / 06期
关键词：
D O I：
10.1038/s43587-021-00077-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease (AD) is characterized by amyloid-beta (A beta)-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on A beta toxicity should be revised.
引用
收藏
页码：498 / 499
页数：2
相关论文
共 50 条
  • [41] Alzheimer's disease: the infectious hypothesis
    Roubaud Baudron, Claire
    Varon, Christine
    Megraud, Francis
    SalleS, Nathalie
    GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT, 2015, 13 (04): : 418 - 424
  • [42] Alzheimer's disease - A hypothesis on pathogenesis
    Harman, D
    TOWARDS PROLONGATION OF THE HEALTHY LIFE SPAN: PRACTICAL APPROACHES TO INTERVENTION, 1998, 854 : 515 - 515
  • [43] A Hypnic Hypothesis of Alzheimer's Disease
    Clark, Camilla N.
    Warren, Jason D.
    NEURODEGENERATIVE DISEASES, 2013, 12 (04) : 165 - 176
  • [44] An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis
    Caselli, Richard J.
    Knopman, David S.
    Bu, Guojun
    ALZHEIMERS & DEMENTIA, 2020, 16 (11) : 1582 - 1590
  • [45] Truncating the amyloid cascade hypothesis:: the role of C-terminal Aβ peptides in Alzheimer's disease
    Teplow, DB
    NEUROBIOLOGY OF AGING, 1999, 20 (01) : 71 - 73
  • [46] The Mitochondrial Cascade Hypothesis for Parkinson's Disease
    Cardoso, Sandra M.
    CURRENT PHARMACEUTICAL DESIGN, 2011, 17 (31) : 3390 - 3397
  • [47] Tau phosphorylation in Alzheimer's disease
    Hanger, D
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2003, 13 : S100 - S100
  • [48] The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
    Patrick L. McGeer
    Edith G. McGeer
    Acta Neuropathologica, 2013, 126 : 479 - 497
  • [49] The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
    McGeer, Patrick L.
    McGeer, Edith G.
    ACTA NEUROPATHOLOGICA, 2013, 126 (04) : 479 - 497
  • [50] From the amyloid hypothesis to the autoimmune hypothesis of Alzheimer's disease
    Lim, Bryant
    Prassas, Ioannis
    Diamandis, Eleftherios P.
    DIAGNOSIS, 2022, 9 (02) : 280 - 281
12345