Synthesis of Quinazolines as Tyrosine Kinase Inhibitors

被引：21

作者：

Srivastava, Sanjay K. ^{[1
]}

Kumar, Vivek ^{[1
]}

Agarwal, Shiv K. ^{[1
]}

Mukherjee, Rama ^{[1
]}

Burman, Anand C. ^{[1
]}

机构：

[1] Dabur Res Fdn, Ghaziabad 201010, UP, India

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 03期

关键词：

GROWTH-FACTOR RECEPTOR; ATP-BINDING-SITE; IRREVERSIBLE INHIBITORS; SELECTIVE INHIBITORS; LAVENDUSTIN-A; PDGF RECEPTOR; POTENT; DERIVATIVES; 4-ANILINOQUINAZOLINES; PHOSPHORYLATION;

D O I：

10.2174/1871520610909030246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It was found that C-4, C-6 and C-7 positions in quinazoline are appropriate sites for designing new tyrosine kinase inhibitors. This review should help the medicinal chemist in designing more effective tyrosine kinase inhibitors.

引用

页码：246 / 275

页数：30

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