Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?

被引：12

作者：

Mallick, Rahul ^{[1
]}

Ylae-Herttuala, Seppo ^{[1
,2
]}

机构：

[1] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio 70211, Finland

[2] Kuopio Univ Hosp, Heart Ctr, Gene Therapy Unit, Kuopio 70029, Finland

来源：

CELLS | 2022年 / 11卷 / 24期

基金：

英国科研创新办公室;

关键词：

angiogenesis; CHD; gene therapy; VEGF-A; VEGF-B; VEGF-R1; NRP-1; heart failure; fatty acid; glucose; FATP; ENDOTHELIAL GROWTH-FACTOR; CARDIAC METABOLISM; CELL-METABOLISM; MOUSE HEART; ANGIOGENESIS; EXPRESSION; GENE; SUGGESTS; MICE; ARTERIOGENESIS;

D O I：

10.3390/cells11244134

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Coronary heart disease (CHD) is the leading cause of death around the world. Based on the roles of vascular endothelial growth factor (VEGF) family members to regulate blood and lymphatic vessels and metabolic functions, several therapeutic approaches have been attempted during the last decade. However proangiogenic therapies based on classical VEGF-A have been disappointing. Therefore, it has become important to focus on other VEGFs such as VEGF-B, which is a novel member of the VEGF family. Recent studies have shown the very promising potential of the VEGF-B to treat CHD and heart failure. The aim of this review article is to present the role of VEGF-B in endothelial biology and as a potential therapeutic agent for CHD and heart failure. In addition, key differences between the VEGF-A and VEGF-B effects on endothelial functions are demonstrated.

引用

页数：13

共 50 条

[1] VEGF-A and VEGF-B Coordinate the Arteriogenesis to Repair the Infarcted Heart with Vagus Nerve Stimulation
Lv, Yan-xia
Zhong, Sen
Tang, Hexin
Luo, Bin
Chen, Shao-Juan
Chen, Long
Zheng, Fei
Zhang, Lei
Wang, Lu
Li, Xing-yuan
Yan, Yu-wen
Pan, Ya-mu
Jiang, Miao
Zhang, You-en
Wang, Lei
Yang, Jian-ye
Guo, Ling-yun
Chen, Shi-you
Wang, Jia-ning
Tang, Jun-ming
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 48 (02) : 433 - 449
[2] VEGF-B: friend or foe to the heart in times of nutrient excess?
Rowe, Glenn C.
Young, Martin E.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2017, 313 (02): : H244 - H247
[3] VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats
Samuelsson, Anne-Maj
Bartolomaeus, Theda Ulrike Patricia
Anandakumar, Harithaa
Thowsen, Irene
Nikpey, Elham
Han, Jianhua
Marko, Lajos
Finne, Kenneth
Tenstad, Olav
Eckstein, Johannes
Berndt, Nikolaus
Kuehne, Titus
Kedziora, Sarah
Sultan, Ibrahim
Skogstrand, Trude
Karlsen, Tine, V
Nurmi, Harri
Forslund, Sofia K.
Bollano, Entela
Alitalo, Kari
Muller, Dominik N.
Wiig, Helge
CARDIOVASCULAR RESEARCH, 2023, 119 (07) : 1553 - 1567
[4] The Role of the VEGF Family in Coronary Heart Disease
Zhou, Yan
Zhu, Xueping
Cui, Hanming
Shi, Jingjing
Yuan, Guozhen
Shi, Shuai
Hu, Yuanhui
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 8
[5] VEGF-B Gene Therapy for the Heart: Proceed with Caution
Giacca, Mauro
Recchia, Fabio A.
MOLECULAR THERAPY, 2020, 28 (07) : 1566 - 1568
[6] Gene therapy for ischaemic heart disease and heart failure
Korpela, H.
Jarvelainen, N.
Siimes, S.
Lampela, J.
Airaksinen, J.
Valli, K.
Turunen, M.
Pajula, J.
Nurro, J.
Yla-Herttuala, S.
JOURNAL OF INTERNAL MEDICINE, 2021, 290 (03) : 567 - 582
[7] VEGF receptor switching in heart development and disease
Madonna, Rosalinda
De Caterina, Raffaele
CARDIOVASCULAR RESEARCH, 2009, 84 (01) : 4 - 6
[8] Potential role of nutritional factors in coronary heart disease and heart failure
Das, Undurti N.
AGRO FOOD INDUSTRY HI-TECH, 2015, 26 (02): : 26 - 30
[9] Angiogenic lncRNAs: A potential therapeutic target for ischaemic heart disease
Xu, Zhi-Meng
Huang, Feng
Huang, Wei-Qiang
LIFE SCIENCES, 2018, 211 : 157 - 171
[10] Novel function of VEGF-B as an antioxidant and therapeutic implications
Chen, Rongyuan
Lee, Chunsik
Lin, Xianchai
Zhao, Chen
Li, Xuri
PHARMACOLOGICAL RESEARCH, 2019, 143 : 33 - 39

← 1 2 3 4 5 →