On the trail of the glycan codes stored in cancer-related cell adhesion proteins

被引:24
作者
Hoja-Lukowicz, Dorota [1 ]
Przybylo, Malgorzata [1 ]
Duda, Malgorzata [2 ]
Pochec, Ewa [1 ]
Bubka, Monika [1 ]
机构
[1] Jagiellonian Univ, Inst Zool, Dept Glycoconjugate Biochem, 9 Gronostajowa St, PL-30387 Krakow, Poland
[2] Jagiellonian Univ, Inst Zool, Dept Endocrinol, 9 Gronostajowa St, PL-30387 Krakow, Poland
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2017年 / 1861卷 / 01期
关键词
Cadherin; Integrin; Immunoglobulin-like superfamily; Cancer; Glycosylation; Biomarker; Protein-carbohydrate interaction; N-ACETYLGLUCOSAMINYLTRANSFERASE-III; EPITHELIAL-MESENCHYMAL TRANSITION; SYNTHETIC EMMPRIN PEPTIDES; TANDEM MASS-SPECTROMETRY; FUCOSYLATED E-CADHERIN; BETA-PROPELLER DOMAIN; NONHUMAN SIALIC-ACID; POLYSIALIC ACID; GROWTH-FACTOR; ALPHA(V)BETA(3) INTEGRIN;
D O I
10.1016/j.bbagen.2016.08.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Changes in the profile of protein glycosylation are a hallmark of ongoing neoplastic transformation. A unique set of tumor-associated carbohydrate antigens expressed on the surface of malignant cells may serve as powerful diagnostic and therapeutic targets. Cell-surface proteins with altered glycosylation affect the growth, proliferation and survival of those cells, and contribute to their acquisition of the ability to migrate and invade. They may also facilitate tumor-induced immunosuppression and the formation of distant metastases. Deciphering the information encoded in these particular glycan portions of glycoconjugates may shed light on the mechanisms of cancer progression and metastasis. A majority of the related review papers have focused on overall changes in the patterns of cell-surface glycans in various cancers, without pinpointing the molecular carriers of these glycan structures. The present review highlights the ways in which particular tumor-associated glycan(s) coupled with a given membrane-bound protein influence neoplastic cell behavior during the development and progression of cancer. We focus on altered glycosylated cell-adhesion molecules belonging to the cadherin, integrin and immunoglobulin-like superfamilies, examined in the context of molecular interactions. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:3237 / 3257
页数:21
相关论文
共 290 条
[1]   N-glycan structures: recognition and processing in the ER [J].
Aebi, Markus ;
Bernasconi, Riccardo ;
Clerc, Simone ;
Molinari, Maurizio .
TRENDS IN BIOCHEMICAL SCIENCES, 2010, 35 (02) :74-82
[2]   N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex [J].
Akama, Ryota ;
Sato, Yuya ;
Kariya, Yoshinobu ;
Isaji, Tomoya ;
Fukuda, Tomohiko ;
Lu, Lianghao ;
Taniguchi, Naoyuki ;
Ozawa, Masayuki ;
Gu, Jianguo .
PROTEOMICS, 2008, 8 (16) :3221-3228
[3]   Glycomic Analysis of Membrane Glycoproteins with Bisecting Glycosylation from Ovarian Cancer Tissues Reveals Novel Structures and Functions [J].
Allam, Heba ;
Aoki, Kazuhiro ;
Benigno, Benedict B. ;
McDonald, John F. ;
Mackintosh, Samuel G. ;
Tiemeyer, Michael ;
Abbott, Karen L. .
JOURNAL OF PROTEOME RESEARCH, 2015, 14 (01) :434-446
[4]   Metabolic Flux Increases Glycoprotein Sialylation: Implications for Cell Adhesion and Cancer Metastasis [J].
Almaraz, Ruben T. ;
Tian, Yuan ;
Bhattarcharya, Rahul ;
Tan, Elaine ;
Chen, Shih-Hsun ;
Dallas, Matthew R. ;
Chen, Li ;
Zhang, Zhen ;
Zhang, Hui ;
Konstantopoulos, Konstantinos ;
Yarema, Kevin J. .
MOLECULAR & CELLULAR PROTEOMICS, 2012, 11 (07)
[5]   L1CAM in human cancer [J].
Altevogt, Peter ;
Doberstein, Kai ;
Fogel, Mina .
INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (07) :1565-1576
[6]   Tumour suppressor p16INK4a-anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model [J].
Amano, Maho ;
Eriksson, Hanna ;
Manning, Joachim C. ;
Detjen, Katharina M. ;
Andre, Sabine ;
Nishimura, Shin-Ichiro ;
Lehtio, Janne ;
Gabius, Hans-Joachim .
FEBS JOURNAL, 2012, 279 (21) :4062-4080
[7]   Importance of N-Glycosylation on CD147 for Its Biological Functions [J].
Bai, Yang ;
Huang, Wan ;
Ma, Li-Tian ;
Jiang, Jian-Li ;
Chen, Zhi-Nan .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (04) :6356-6377
[8]  
Baldwin G.S., 2012, THESIS
[9]   Tetraspanin CD151 Regulates Glycosylation of α3β1 Integrin [J].
Baldwin, Gouri ;
Novitskaya, Vera ;
Sadej, Rafal ;
Pochec, Ewa ;
Litynska, Anna ;
Hartmann, Christoph ;
Williams, Janelle ;
Ashman, Leonie ;
Eble, Johannes A. ;
Berditchevski, Fedor .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (51) :35445-35454
[10]   Targeting cancer stem cells through L1CAM suppresses glioma growth [J].
Bao, Shideng ;
Wu, Qiulian ;
Li, Zhizhong ;
Sathornsumetee, Sith ;
Wang, Hui ;
McLendon, Roger E. ;
Hjehneland, Anita B. ;
Rich, Jeremy N. .
CANCER RESEARCH, 2008, 68 (15) :6043-6048