Farnesides A and B, Sesquiterpenoid Nucleoside Ethers from a Marine-Derived Streptomyces sp., strain CNT-372 from Fiji

被引：18

作者：

Ilan, Ella Zafrir ^{[1
]}

Torres, Manuel R. ^{[2
,3
]}

Prudhomme, Jacques ^{[2
,3
]}

Le Roch, Karine ^{[2
,3
]}

Jensen, Paul R. ^{[1
]}

Fenical, William ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

[2] Univ Calif Riverside, Inst Integrat Genome Biol, Ctr Dis Vector Res, Riverside, CA 92521 USA

[3] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期

基金：

美国国家卫生研究院;

关键词：

BACTERIUM;

D O I：

10.1021/np400351t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Famesides A and B (1, 2), linear sesquiterpenoids connected by ether links to a ribose dihydrouracil nucleoside, were isolated from a marine-derived Streptomyces sp., strain CNT-372, grown in saline liquid culture. The structures of the new compounds were assigned by comprehensive spectroscopic analysis primarily involving ID and 2D NMR analysis and by comparison of spectroscopic data to the recently reported ribose nucleoside JBIR-68 (3). The farnesides are only the second example of this exceedingly rare class of microbial terpenoid nucleoside metabolites. Farneside A (1) was found to have modest antimalarial activity against the parasite Plasmodium falciparum.

引用

页码：1815 / 1818

页数：4

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