Sepsis-Induced Acute Kidney Injury

被引：84

作者：

Martensson, Johan ^{[1
,2
]}

Bellomo, Rinaldo ^{[1
,3
]}

机构：

[1] Austin Hosp, Dept Intens Care, Heidelberg, Vic 3084, Australia

[2] Karolinska Inst, Dept Physiol & Pharmacol, Sect Anaesthesia & Intens Care Med, S-17177 Stockholm, Sweden

[3] Monash Univ, Dept Epidemiol & Prevent Med, Australian & New Zealand Intens Care Res Ctr, Sch Prevent Med & Publ Hlth, Melbourne, Vic 3004, Australia

来源：

CRITICAL CARE CLINICS | 2015年 / 31卷 / 04期

关键词：

Sepsis; Acute kidney injury; Inflammation; Renal replacement therapy; CRITICALLY-ILL PATIENTS; RENAL-REPLACEMENT THERAPY; CONTINUOUS VENOVENOUS HEMOFILTRATION; BLOOD-CELL TRANSFUSION; SEPTIC SHOCK; INFLAMMATORY RESPONSES; VOLUME HEMOFILTRATION; ALKALINE-PHOSPHATASE; CONTROLLED-TRIAL; DOUBLE-BLIND;

D O I：

10.1016/j.ccc.2015.06.003

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Acute kidney injury (AKI) is a serious yet potentially reversible complication of sepsis. Several molecular mechanisms involved in the development of septic AKI have been identified. These mechanisms may be important targets in the development of future therapies. This review highlights the role of the innate immune response to sepsis and its downstream effects on kidney structure and function with special reference to the adaptive cellular response and glomerular hemodynamic changes. In addition, current evidence surrounding the management of patients with septic AKI is summarized. Finally, potential novel therapies for septic AKI are presented.

引用

页码：649 / 660

页数：12

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