Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study

被引:18
作者
Mitchell, Nicole J. [1 ]
Riley, Ronald T. [2 ]
Egner, Patricia A. [3 ]
Groopman, John D. [3 ]
Wu, Felicia [1 ]
机构
[1] Michigan State Univ, Dept Food Sci & Human Nutr, 469 Wilson Rd, E Lansing, MI 48824 USA
[2] ARS, Toxicol & Mycotoxin Res Unit, Natl Poultry Dis Res Ctr, RB Russell Res Ctr,USDA, Athens, GA USA
[3] Johns Hopkins Univ, Dept Environm Hlth Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
基金
美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;
关键词
aflatoxin; child growth; Nepal; preliminary exposure; SERUM-ALBUMIN ADDUCTS; DIETARY AFLATOXIN; YOUNG-CHILDREN; WEST-AFRICA; GROWTH; MYCOTOXINS; FUMONISIN; MAIZE; BENIN; RISK;
D O I
10.1038/jes.2015.87
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposure to aflatoxin, a mycotoxin common in maize and groundnuts, has been associated with childhood stunting in sub-Saharan Africa. In an effort to further our understanding of growth impairment in relation to mycotoxins and other risk factors, biospecimens from a cohort of children enrolled in the Bhaktapur, Nepal MAL-ED study were assessed for aflatoxin exposure at 15, 24, and 36 months of age. Exposure was assessed through a well-established serum biomarker, the AFB(1)-lysine adduct. In this manuscript, the levels of aflatoxin exposure in the Nepal cohort were compared with those observed in aflatoxin studies, with child growth parameters as a health outcome. Results from this preliminary analysis demonstrated chronic aflatoxin exposure in children residing in Bhaktapur with a geometric mean of 3.62 pg AFB(1)-lysine/mg albumin. The range of exposure in this population is similar to those in African populations where associations with aflatoxin biomarkers and poor child growth have been observed. Future work will analyze the relationships between aflatoxin levels, growth, and other risk factors collected by the MAL-ED study.
引用
收藏
页码:106 / 111
页数:6
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