Magnetic nanoparticles as contrast agents in the diagnosis and treatment of cancer

被引：190

作者：

Gallo, Juan ^{[1
,2
]}

Long, Nicholas J. ^{[1
,2
]}

Aboagye, Eric O. ^{[2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Comprehens Canc Imaging Ctr, London W12 0NN, England

来源：

CHEMICAL SOCIETY REVIEWS | 2013年 / 42卷 / 19期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

SUPERPARAMAGNETIC IRON-OXIDE; CORE-SHELL NANOPARTICLES; IN-VIVO; OXIDATIVE STRESS; MRI CONTRAST; SURFACE FUNCTIONALIZATION; TRANSFERRIN RECEPTOR; RESONANCE DETECTION; FEPT NANOPARTICLES; CELLULAR UPTAKE;

D O I：

10.1039/c3cs60149h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic nanoparticles represent one of the most advanced developments in the application of nanotechnology to human health. To date, their clinical application has been restricted to the diagnosis of hepatic lesions and lymph node metastasis but functionalization of these materials with biomolecules as targeting motifs, and the inclusion of therapeutic drugs in their composition, is certain to make a substantial impact within biomedicine. One of the diseases that could benefit from these advances is cancer, as early diagnosis and effective treatment are crucial for a patient's survival and quality of life. This review will examine the recent uses of magnetic particles in cancer diagnosis and treatment.

引用

收藏

页码：7816 / 7833

页数：18

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