Improved synthesis of the northern hemisphere of epothilone A by a sharpless asymmetric dihydroxylation

被引：18
|
作者：
Quitschalle, M [1 ]
Kalesse, M [1 ]
机构：
[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 44期
关键词：
D O I：
10.1016/S0040-4039(99)01659-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An improved synthesis of the northern hemisphere of epothilone A is described. This approach utilizes the Sharpless asymmetric dihydroxylation of 5-hexen-2-one (allyl acetone) to generate the precursor for the Wittig reaction and the subsequent ring closing metathesis reaction (RCM). This strategy allows to generate precursor 13 as both enantiomers from ready available starting material in a very efficient manner. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7765 / 7768
页数：4
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