The role of vitamin D and P2X7R in multiple sclerosis

被引：5
|
作者：
Voo, Veronica Tsin Fong [1 ,2 ]
O'Brien, Terence [2 ,3 ]
Butzkueven, Helmut [2 ]
Monif, Mastura [1 ,2 ,3 ]
机构：
[1] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia
[2] Monash Univ, Dept Neurosci, Melbourne, Vic, Australia
[3] Melbourne Hlth, Dept Neurol, Melbourne, Vic, Australia
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 330卷
关键词：
Multiple sclerosis; Neuroinflammation; P2X7R; Vitamin D; Innate immunity; Monocytes; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TOLL-LIKE RECEPTORS; P2X(7) RECEPTOR; T-CELLS; HUMAN MONOCYTES; FUNCTIONAL-CHARACTERIZATION; 25-HYDROXYVITAMIN-D LEVELS; DOSE CHOLECALCIFEROL; PURINERGIC RECEPTOR; CEREBROSPINAL-FLUID;
D O I：
10.1016/j.jneuroim.2019.03.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.
引用
收藏
页码：159 / 169
页数：11
相关论文
共 50 条
  • [1] Vitamin D modulation on P2X7 receptor in Multiple Sclerosis
    Voo, V. T. F.
    O'Brien, T.
    Butzkueven, H.
    Monif, M.
    MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (03) : NP33 - NP34
  • [2] Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis
    Beaino, Wissam
    Janssen, Bieneke
    Kooij, Gijs
    van der Pol, Susanne M. A.
    Hof, B. van Het
    van Horssen, Jack
    Windhorst, Albert D.
    de Vries, Helga E.
    JOURNAL OF NEUROINFLAMMATION, 2017, 14
  • [3] Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis
    Wissam Beaino
    Bieneke Janssen
    Gijs Kooij
    Susanne M. A. van der Pol
    B. van Het Hof
    Jack van Horssen
    Albert D. Windhorst
    Helga E. de Vries
    Journal of Neuroinflammation, 14
  • [4] Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients
    Agliardi, Cristina
    Guerini, Franca Rosa
    Zanzottera, Milena
    Bolognesi, Elisabetta
    Caputo, Domenico
    Rovaris, Marco
    Clerici, Mario
    NEUROBIOLOGY OF DISEASE, 2024, 199
  • [5] The role of vitamin D in multiple sclerosis
    Kfoczynska, Medea
    Kucharska, Alicja
    Sinska, Beata
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2015, 69 : 440 - 446
  • [6] The role of P2X7R in neuroinflammation and implications in Alzheimer's disease
    Chen, Yi-He
    Lin, Rong-Rong
    Tao, Qing-Qing
    LIFE SCIENCES, 2021, 271
  • [7] The role of vitamin D in multiple sclerosis
    Kampman, Margitta T.
    Steffensen, Linn H.
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2010, 101 (02) : 137 - 141
  • [8] The role of vitamin D in multiple sclerosis
    Brown, SJ
    ANNALS OF PHARMACOTHERAPY, 2006, 40 (06) : 1158 - 1161
  • [9] The Role of Vitamin D in Neuroprotection in Multiple Sclerosis: An Update
    Sangha, Amarpreet
    Quon, Michaela
    Pfeffer, Gerald
    Orton, Sarah-Michelle
    NUTRIENTS, 2023, 15 (13)
  • [10] PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139
    Beaino, Wissam
    Janssen, Bieneke
    Kooijman, Esther
    Vos, Ricardo
    Schuit, Robert C.
    O'Brien-Brown, James
    Kassiou, Michael
    van het Hof, Bert
    Vugts, Danielle J.
    de Vries, Helga E.
    Windhorst, Albert D.
    JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)
12345