Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes

被引：15

作者：

Yasukawa, Shinsuke ^{[2
]}

Dainichi, Teruki ^{[1
]}

Kokuba, Hisashi ^{[2
]}

Moroi, Yoichi ^{[2
]}

Urabe, Kazunori ^{[2
]}

Hashimoto, Takashi ^{[1
]}

Furue, Masutaka ^{[2
]}

机构：

[1] Kurume Univ, Sch Med, Dept Dermatol, Fukuoka 8300011, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka 812, Japan

来源：

EUROPEAN JOURNAL OF DERMATOLOGY | 2009年 / 19卷 / 01期

关键词：

pustular psoriasis; bullous pemphigoid; Th1; Th2; Th17; REGULATORY T-CELLS; VULGARIS LESIONS; T(H)17; INFLAMMATION; POPULATIONS; PATHWAYS; LINEAGE; TYPE-1;

D O I：

10.1684/ejd.2008.0572

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis vulgaris is occasionally accompanied by autoimmune bullous diseases, but the opposite is very rare. We document here the first reported case of generalized pustular psoriasis that appeared during steroid therapy for bullous pemphigoid. The serum cytokine levels and the results of an immunohistochemical study over the disease course suggest that the immunological state was consistent with a shift from Th2-dominance to Th1-dominance. IL-17-producing cells appeared in the skin lesions when each disease was most exacerbated and disappeared after remission. Thus, the present case demonstrated a dynamic immunological state in which the appearances of Th1 and Th2 as well as Th17 varied during the course of the disease.

引用

页码：69 / 71

页数：3

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