Preliminary evaluation of pharmacological properties of some xanthone derivatives

被引：46

作者：

Marona, Henryk ^{[1
]}

Szkaradek, Natalia ^{[1
,2
]}

Rapacz, Anna ^{[3
]}

Filipek, Barbara ^{[3
,4
]}

Dybala, Malgorzata ^{[5
]}

Siwek, Agata ^{[5
]}

Cegla, Marek ^{[2
]}

Szneler, Edward ^{[6
]}

机构：

[1] Jagiellonian Univ, Coll Med, Fac Pharm, Dept Technol & Biotechnol Drugs, PL-30688 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Fac Pharm, Dept Organ Chem, PL-30688 Krakow, Poland

[3] Jagiellonian Univ, Coll Med, Fac Pharm, Dept Pharmacodynam, PL-30688 Krakow, Poland

[4] Jagiellonian Univ, Coll Med, Fac Pharm, Lab Pharmacol Screening, PL-30688 Krakow, Poland

[5] Jagiellonian Univ, Coll Med, Fac Pharm, Lab Pharmacobiol,Dept Cytobiol, PL-30688 Krakow, Poland

[6] Jagiellonian Univ, Fac Chem, PL-30688 Krakow, Poland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 03期

关键词：

Xanthones; Antiarrhythmic; hypotensive and anticonvulsive activities; Radioligand-binding assay; AMINOALKANOLIC DERIVATIVES; HYPOTENSIVE PROPERTIES; PROPRANOLOL; DRUGS;

D O I：

10.1016/j.bmc.2008.12.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)- adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1345 / 1352

页数：8

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