CC-122 immunomodulatory effects in refractory patients with diffuse large B-cell lymphoma

被引：17

作者：

Cubillos-Zapata, Carolina ^{[1
,2
,3
]}

Cordoba, Raul ^{[4
,5
]}

Avendano-Ortiz, Jose ^{[1
,2
]}

Arribas-Jimenez, Cristina ^{[1
,2
]}

Hernandez-Jimenez, Enrique ^{[1
,2
,3
]}

Toledano, Victor ^{[1
,2
,3
]}

Villaescusa, Teresa ^{[4
,5
]}

Moreno, Victor ^{[4
,5
]}

Lopez-Collazo, Eduardo ^{[1
,2
,3
]}

机构：

[1] La Paz Univ Hosp, Innate Immune Response Grp, IdiPAZ, Madrid, Spain

[2] IdiPAZ, Tumor Immunol Lab, Madrid, Spain

[3] CIBEres, Ctr Biomed Res Network, Madrid, Spain

[4] Autonomous Univ Madrid, Hlth Res Inst IIS FJS, Fdn Jimenez Diaz Univ Hosp, Lymphoma Unit,Oncohlth Inst, Madrid, Spain

[5] Fdn Jimenez Diaz Univ Hosp, Phase Clin Trials Unit 1, START Madrid FJD, Madrid, Spain

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 12期

关键词：

CC-122; treatment; DLBCL patients; immune response; SUPPRESSOR-CELLS; T-CELLS; IMMUNE ESCAPE; PATHWAY;

D O I：

10.1080/2162402X.2016.1231290

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the three patients included in a phase I clinical trial (NCT01421524), we report the immunomodulatory effects and efficacy of CC-122, a novel pleiotropic pathway modifier compound originally developed for broad diffuse large B-cell lymphoma (DLBCL). The chemical structure of CC-122 includes the glutarimide moiety that is known to modulate the immune response. The immunomodulatory agents including lenalidomide represent a promising therapeutic strategy targeting tumors in B-cell lymphoid malignancies. We observed that CC-122 might regulate the NK phenotype and its activity due to the reduced accumulation of myeloid-derived suppressor cell and eventually decrease the Tregs subsets. Finally, the activation of T cells through costimulatory molecule (CD28) was detected as a delayed CC-122 effect. In this context, CC-122 arises as an alternative option for DLBCL patients refractory to the traditional chemotherapeutic agents.

引用

页数：5

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