Localized Cortical Thinning in Patients with Obstructive Sleep Apnea Syndrome

被引:79
作者
Joo, Eun Yeon [1 ]
Jeon, Seun [2 ]
Kim, Sung Tae [3 ]
Lee, Jong-Min [2 ]
Hong, Seung Bong [1 ]
机构
[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med,SBRI, Seoul 135710, South Korea
[2] Hanyang Univ, Dept Biomed Engn, Computat NeuroImage Anal Lab, Seoul 133791, South Korea
[3] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiol, Sch Med, Seoul 135710, South Korea
关键词
Brain; cortical thickness; MRI; obstructive sleep apnea; AUTOMATED 3-D EXTRACTION; BRAIN MORPHOLOGY; STRUCTURAL-CHANGES; PREFRONTAL CORTEX; BLOOD-FLOW; THICKNESS; RESPONSES; VOLUME; MORPHOMETRY; IMPAIRMENT;
D O I
10.5665/sleep.2876
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: To investigate differences in cortical thickness in patients with obstructive sleep apnea (OSA) syndrome and healthy controls. Design: Cortical thickness was measured using a three-dimensional surface-based method that enabled more accurate measurement in deep sulci and localized regional mapping. Setting: University hospital. Patients: Thirty-eight male patients with severe OSA (mean apnea-hypopnea index > 30/h) and 36 age-matched male healthy controls were enrolled. Interventions: Cortical thickness was obtained at 81,924 vertices across the entire brain by reconstructing inner and outer cortical surfaces using an automated anatomical pipeline. Measurements: Group difference in cortical thickness and correlation between patients' data and thickness were analyzed by a general linear model. Results: Localized cortical thinning in patients was found in the orbitorectal gyri, dorsolateral/ventromedial prefrontal regions, pericentral gyri, anterior cingulate, insula, inferior parietal lobule, uncus, and basolateral temporal regions at corrected P < 0.05. Patients with OSA showed impaired attention and learning difficulty in memory tests compared to healthy controls. Higher number of respiratory arousals was related to cortical thinning of the anterior cingulate and inferior parietal lobule. A significant correlation was observed between the longer apnea maximum duration and the cortical thinning of the dorsolateral prefrontal regions, pericentral gyri, and insula. Retention scores in visual memory tests were associated with cortical thickness of parahippocampal gyrus and uncus. Conclusions: Brain regions with cortical thinning may provide elucidations for prefrontal cognitive dysfunction, upper airway sensorimotor dysregulation, and cardiovascular disturbances in OSA patients, that experience sleep disruption including sleep fragmentation and oxygen desaturation.
引用
收藏
页码:1153 / 1162
页数:10
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