Electrochemical Determination of Moxifloxacin Hydrochloride Based on Molecularly Imprinted Polymer Modified Carbon Paste Electrode

被引：0
|
作者：
Zhou, Qing [1 ]
Long, Ning [1 ]
Liu, Lan [2 ]
Zhai, Haiyun [1 ]
Zhu, Mingfang [1 ]
机构：
[1] GuangDong Pharmaceut Univ, Dept Pharm, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2015年 / 10卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Moxifloxacin Hydrochloride; precipitation polymerization; molecularly imprinted polymer; modified electrode; carbon paste electrode; LIQUID-CHROMATOGRAPHY ASSAY; PHARMACOKINETICS; VALIDATION;
D O I：
暂无
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
A highly selective molecularly imprinted polymer modified carbon paste electrode was developed. The Moxifloxacin Hydrochloride molecularly imprinted polymer was synthesized by thermal initiation precipitation polymerization, and the modified electrode was prepared by mixing graphite and polymer (90:10). Studied the electrochemical behavior and established the determination method of Moxifloxacin Hydrochloride at the electrode. The results showed that the sensor has high selectivity and sensitivity. and exhibited a linear voltammetric response for Moxifloxacin Hydrochloride in the concentration range of 3.13x10(-6)similar to 2.0x10(-4)mol.L-1, with the limit of detection (LOD) of 5.9x10(-8)mol.L-1 (S/N=3). The sensor was applied to determine Moxifloxacin Hydrochloride in Avelox tablets and and human serum samples. The recoveries of Moxifloxacin Hydrochloride ranged from 97.2% to 104.5%.
引用
收藏
页码：5069 / 5076
页数：8
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