Acquired Dysfibrinogenemia Secondary to Multiple Myeloma

被引：34

作者：

Kotlin, Roman ^{[1
]}

Sobotkova, Alzbeta ^{[1
]}

Riedel, Tomas ^{[1
]}

Salaj, Peter ^{[1
]}

Suttnar, Jiri ^{[1
]}

Reicheltova, Zuzana ^{[1
]}

Majek, Pavel ^{[1
]}

Khaznadar, Tarek ^{[1
]}

Dyr, Jan E. ^{[1
]}

机构：

[1] Inst Hematol & Blood Transfus, CR-12820 Prague 2, Czech Republic

来源：

ACTA HAEMATOLOGICA | 2008年 / 120卷 / 02期

关键词：

Acquired dysfibrinogenemia; Amorphous clot; Fibrinogen; Multiple myeloma; Paraprotein;

D O I：

10.1159/000160182

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abnormal coagulation properties indicative of a dysfibrinogen were found in the plasma of a 72-year-old male with multiple myeloma (IgG kappa, stage IIIA). The patient had high paraprotein concentration (85.75 g/l) and prolonged thrombin time (76.8 s), activated partial thromboplastin time (39.5 s), prothrombin time (23.5 s) and reptilase time (72.0 s). The fibrinogen level was increased. The fibrin polymerization induced by both thrombin and reptilase was impaired. Scanning electron microscopy revealed abnormal clot morphology. After six months of treatment, the paraprotein level decreased (19.48 g/l) and coagulation normalized as well as fibrin polymerization and fibrin clot morphology. It was found that the paraprotein interacts with the gamma-chain of fibrinogen. Acquired dysfibrinogenemia associated with multiple myeloma was diagnosed in the 72-year-old patient. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：75 / 81

页数：7

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