Acetaminophen toxicity up-regulates MRP2 expression in the liver of cats: an old story with new vision

被引：2

作者：

Malekinejad, Hassan ^{[1
]}

Varasteh, Soheyl ^{[2
,3
]}

Rahmani, Fatemeh ^{[4
]}

Cheraghi, Hadi ^{[5
]}

Alizadeh, Arash ^{[3
]}

Behfar, Mehdi ^{[6
]}

机构：

[1] Urmia Univ, Dept Pharmacol & Toxicol, Fac Vet Med, Orumiyeh, Iran

[2] Univ Utrecht, Fac Sci, Div Vet Pharm Pharmacol & Toxicol, Utrecht, Netherlands

[3] Univ Utrecht, Inst Pharmaceut Sci, Fac Sci, Utrecht, Netherlands

[4] Urmia Univ, Fac Basic Sci, Dept Genet, Orumiyeh, Iran

[5] Univ Tehran, Dept Clin Pathol, Fac Vet Med, Tehran, Iran

[6] Urmia Univ, Dept Clin Sci, Fac Vet Med, Orumiyeh, Iran

来源：

TOXIN REVIEWS | 2015年 / 34卷 / 02期

关键词：

Acetaminophen; efflux transporter; hepatotoxicity; oxidative/nitrosative stress; NITRIC-OXIDE; HEPATOTOXICITY; RESISTANCE; MECHANISMS; DEFICIENT; GENE; DOGS; RAT;

D O I：

10.3109/15569543.2015.1027829

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This study was conducted to clarify the role of efflux transporter MRP2 in acetaminophen-induced hepatotoxicity in cats. Sixteen mixed bred male cats and four liver samples from mixed breed male dogs were used. The cats were assigned into four groups (n = 4), received saline and 2, 10 and 50 mg/kg doses of acetaminophen orally for 14 days. Unlike the intact dogs, the MRP2 was not detectable in control cats. MRP2 at mRNA level was expressed in the liver of cats, which received the medium and high doses. Data suggest that the MRP2 expression may involve in the acetaminophen-induced hepatotoxicity in cats.

引用

页码：101 / 108

页数：8