MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer

被引:46
作者
Dai, Lei [1 ]
Wang, Yaozong [1 ]
Chen, Liangliang [1 ]
Zheng, Jueru [1 ]
Li, Jianjun [1 ]
Wu, Xianjiang [1 ]
机构
[1] Ningbo 2 Hosp, Dept Thyroid Surg, 41 Xibei St, Ningbo 315000, Zhejiang, Peoples R China
关键词
Papillary thyroid cancer; Recurrence; Biomarker; miR-221; CARCINOMA; EXPRESSION; GENES; DISSECTION; MICRORNAS;
D O I
10.1186/s12957-016-1086-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear. Methods: The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO. 2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis. Results: A total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P < 0.05). The tissue expression of miR-221 was the only independent risk factor for PTC recurrence (HR 1.41; 95% CI 1.14-1.95, P = 0.007) by multiple Cox proportional hazard analysis. Conclusions: This study identified the potential role of miR-221 as a prognostic biomarker for the recurrence in PTC.
引用
收藏
页数:6
相关论文
共 38 条
[1]   Serum microRNAs as non-invasive biomarkers for cancer [J].
Brase, Jan C. ;
Wuttig, Daniela ;
Kuner, Ruprecht ;
Sueltmann, Holger .
MOLECULAR CANCER, 2010, 9
[2]   Changes in circulating microRNA levels associated with prostate cancer [J].
Bryant, R. J. ;
Pawlowski, T. ;
Catto, J. W. F. ;
Marsden, G. ;
Vessella, R. L. ;
Rhees, B. ;
Kuslich, C. ;
Visakorpi, T. ;
Hamdy, F. C. .
BRITISH JOURNAL OF CANCER, 2012, 106 (04) :768-774
[3]  
CADY B, 1988, SURGERY, V104, P947
[4]   Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].
Calin, GA ;
Dumitru, CD ;
Shimizu, M ;
Bichi, R ;
Zupo, S ;
Noch, E ;
Aldler, H ;
Rattan, S ;
Keating, M ;
Rai, K ;
Rassenti, L ;
Kipps, T ;
Negrini, M ;
Bullrich, F ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529
[5]  
Chen YT, 2008, MODERN PATHOL, V21, P1139, DOI 10.1038/modpathol.2008.105
[6]   miR-146b is Highly Expressed in Adult Papillary Thyroid Carcinomas with High Risk Features Including Extrathyroidal Invasion and the BRAFV600E Mutation [J].
Chou, Chen-Kai ;
Chen, Rong-Fu ;
Chou, Fong-Fu ;
Chang, Hsueh-Wen ;
Chen, Yi-Ju ;
Lee, Ya-Fang ;
Yang, Kuender D. ;
Cheng, Jiin-Tsuey ;
Huang, Chao-Cheng ;
Liu, Rue-Tsuan .
THYROID, 2010, 20 (05) :489-494
[7]   Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer [J].
Coarfa, C. ;
Fiskus, W. ;
Eedunuri, V. K. ;
Rajapakshe, K. ;
Foley, C. ;
Chew, S. A. ;
Shah, S. S. ;
Geng, C. ;
Shou, J. ;
Mohamed, J. S. ;
O'Malley, B. W. ;
Mitsiades, N. .
ONCOGENE, 2016, 35 (18) :2345-2356
[8]   Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer [J].
Cooper, David S. ;
Doherty, Gerard M. ;
Haugen, Bryan R. ;
Kloos, Richard T. ;
Lee, Stephanie L. ;
Mandel, Susan J. ;
Mazzaferri, Ernest L. ;
McIver, Bryan ;
Pacini, Furio ;
Schlumberger, Martin ;
Sherman, Steven I. ;
Steward, David L. ;
Tuttle, R. Michael .
THYROID, 2009, 19 (11) :1167-1214
[9]   Molecular fine-needle aspiration biopsy diagnosis of thyroid nodules by tumor specific mutations and gene expression patterns [J].
Eszlinger, Markus ;
Paschke, Ralf .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 322 (1-2) :29-37
[10]   Recurrence of papillary thyroid cancer after optimized surgery [J].
Grant, Clive S. .
GLAND SURGERY, 2015, 4 (01) :52-62