Hepatitis B virus infection in northern Uganda: Impact of pentavalent hepatitis B vaccination

被引:8
作者
Teshale, Eyasu H. [1 ]
Kamili, Saleem [1 ]
Drobeniuc, Jan [1 ]
Denniston, Maxine [1 ]
Bakamutamaho, Barnabas [2 ]
Downing, Robert [2 ]
机构
[1] CDC, Div Viral Hepatitis, Atlanta, GA 30333 USA
[2] Uganda Virus Res Inst, Entebbe, Uganda
关键词
Hepatitis B virus; Pentavalent vaccine; Prevalence; Birth-dose; Mother-to-infant transmission;
D O I
10.1016/j.vaccine.2015.09.058
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Chronic hepatitis B virus infection (CHBI) is effectively prevented by vaccination starting at birth. Beginning in 2002 Uganda adopted a policy of providing the pentavalent hepatitis B vaccine starting at 6 weeks of age. However, there is concern that this delay may leave the infant vulnerable to infection during the first 6 weeks of life. We assessed whether vaccination at 6 weeks was an effective strategy by HBV serologic study. Of 656 persons tested for HBV, 9.4% were chronically infected; among children aged 5-9 years the prevalence was 7.6%. Of all tested, 73 were born (i.e., aged <= 4 years) after the introduction of the pentavalent vaccine; none were infected with HBV (p = 0.003). In this study, vaccination with the pentavalent vaccine at 6 weeks did not result in CHBI, but rather provides an opportunity to prevent mother-to-infant transmission of HBV infection where there is no access to birth-dose vaccine. (C) 2015 Published by Elsevier Ltd.
引用
收藏
页码:6161 / 6163
页数:3
相关论文
共 50 条
[21]   Hepatitis B virus genotypes in korea: An endemic area of hepatitis B virus infection [J].
Song, BC ;
Cui, XJ ;
Kim, HU .
INTERVIROLOGY, 2005, 48 (2-3) :133-137
[22]   Chronic Hepatitis B and Hepatitis D Virus Infection [J].
Rusignuolo, Giuseppe ;
Thimme, Robert ;
Neumann-Haefelin, Christoph .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2024, 149 (16) :948-954
[23]   Impact of hepatitis B virus and hepatitis C virus infection on sperm parameters of infertile men [J].
Karamolahi, Sana ;
Yazdi, Reza Salman ;
Zangeneh, Mehrangiz ;
Makiani, Mahin Jamshidi ;
Farhoodi, Behnam ;
Gilani, Mohammad Ali Sedighi .
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE, 2019, 17 (08) :551-556
[24]   Hepatitis B virus infection in adolescents in a rural township - 15 years subsequent to mass hepatitis B vaccination in Taiwan [J].
Lu, SN ;
Chen, CH ;
Chen, TM ;
Lee, PL ;
Wang, JH ;
Tung, HD ;
Hung, CH ;
Lee, CM ;
Changchien, CS .
VACCINE, 2006, 24 (06) :759-765
[25]   Trend in incidence of hepatitis B virus infection during a decade of universal childhood hepatitis B vaccination in Saudi Arabia [J].
Madani, Tariq A. .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2007, 101 (03) :278-283
[26]   Hepatitis B vaccination and risk of hepatitis B infection in HIV-infected individuals [J].
Landrum, Michael L. ;
Hullsiek, Katherine Huppler ;
Ganesan, Anuradha ;
Weintrob, Amy C. ;
Crum-Cianflone, Nancy F. ;
Barthel, R. Vincent ;
O'Connell, Robert J. ;
Fieberg, Ann ;
Chun, Helen M. ;
Marconi, Vincent C. ;
Dolan, Matthew J. ;
Agan, Brian K. .
AIDS, 2010, 24 (04) :545-555
[27]   Molecular epidemiology of chronic hepatitis B virus infection in northern Poland [J].
Bielawski, Krzysztof Piotr ;
Stalke, Piotr .
JOURNAL OF CLINICAL VIROLOGY, 2005, 34 :S63-S69
[28]   The impact of biologic response modifiers on hepatitis B virus infection [J].
Carroll, Matthew B. .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2011, 11 (04) :533-544
[29]   Hepatitis B virus infection and pregnancy [J].
Pol, Stanislas ;
Corouge, Marion ;
Fontaine, Helene .
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2011, 35 (10) :618-622
[30]   A diagnosis of hepatitis B virus infection [J].
Malbos, Damien .
ACTUALITES PHARMACEUTIQUES, 2020, 59 (601) :27-28