iPSC technology to study human aging and aging-related disorders

被引：48

作者：

Liu, Guang-Hui ^{[1
,2
]}

Ding, Zhichao ^{[1
]}

Izpisua Belmonte, Juan Carlos ^{[2
,3
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China

[2] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

[3] Ctr Regenerat Med Barcelona, Barcelona 08003, Spain

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 06期

基金：

中国国家自然科学基金;

关键词：

PLURIPOTENT STEM-CELLS; FAMILIAL ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; DOPAMINERGIC-NEURONS; SENESCENCE; GENERATION; MUTATIONS; TELOMERES; MOUSE; DIFFERENTIATION;

D O I：

10.1016/j.ceb.2012.08.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.

引用

页码：765 / 774

页数：10

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