iPSC technology to study human aging and aging-related disorders

被引：48
作者：
Liu, Guang-Hui [1 ,2 ]
Ding, Zhichao [1 ]
Izpisua Belmonte, Juan Carlos [2 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
[2] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
[3] Ctr Regenerat Med Barcelona, Barcelona 08003, Spain
来源：
CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 06期
基金：
中国国家自然科学基金;
关键词：
PLURIPOTENT STEM-CELLS; FAMILIAL ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; DOPAMINERGIC-NEURONS; SENESCENCE; GENERATION; MUTATIONS; TELOMERES; MOUSE; DIFFERENTIATION;
D O I：
10.1016/j.ceb.2012.08.014
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.
引用
收藏
页码：765 / 774
页数：10
相关论文
共 50 条
  • [1] The Function of Metformin in Aging-Related Musculoskeletal Disorders
    Song, Yanhong
    Wu, Ziyi
    Zhao, Ping
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [2] Systemic aging and aging-related diseases
    Li, Qiao
    Xiao, Nanyin
    Zhang, Heng
    Liang, Guangyu
    Lin, Yan
    Qian, Zonghao
    Yang, Xiao
    Yang, Jiankun
    Fu, Yanguang
    Zhang, Cuntai
    Liu, Anding
    FASEB JOURNAL, 2025, 39 (05)
  • [3] Aging-related inflammation in osteoarthritis
    Greene, M. A.
    Loeser, R. F.
    OSTEOARTHRITIS AND CARTILAGE, 2015, 23 (11) : 1966 - 1971
  • [4] Research Progress of Aging-related MicroRNAs
    Chen, Zhongyu
    Li, Chenxu
    Huang, Haitao
    Shi, Yi-Ling
    Wang, Xiaobo
    CURRENT STEM CELL RESEARCH & THERAPY, 2024, 19 (03) : 334 - 350
  • [5] A review on the role of RNA methylation in aging-related diseases
    Wei, Hong
    Xu, Yuhao
    Lin, Li
    Li, Yuefeng
    Zhu, Xiaolan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 254
  • [6] The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders
    Smith, Derek K.
    He, Miao
    Zhang, Chun-Li
    Zheng, Jialin C.
    PROGRESS IN NEUROBIOLOGY, 2017, 157 : 212 - 229
  • [7] The paradox of aging: Aging-related shifts in T cell function and metabolism
    Quinn, Kylie M.
    Vicencio, Daniela M.
    La Gruta, Nicole L.
    SEMINARS IN IMMUNOLOGY, 2023, 70
  • [8] Aging-related changes in oxidative stress response of human endothelial cells
    Conti, Valeria
    Corbi, Graziamaria
    Simeon, Vittorio
    Russomanno, Giusy
    Manzo, Valentina
    Ferrara, Nicola
    Filippelli, Amelia
    AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2015, 27 (04) : 547 - 553
  • [9] Aging-related changes in oxidative stress response of human endothelial cells
    Valeria Conti
    Graziamaria Corbi
    Vittorio Simeon
    Giusy Russomanno
    Valentina Manzo
    Nicola Ferrara
    Amelia Filippelli
    Aging Clinical and Experimental Research, 2015, 27 : 547 - 553
  • [10] Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma
    Gnanavel, Mutharasu
    Murugesan, Akshaya
    Konda Mani, Saravanan
    Yli-Harja, Olli
    Kandhavelu, Meenakshisundaram
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (02) : 1 - 14
12345