The role of microRNAs in B-cell development and function

被引：33
作者：
Li, Jingyi [1 ,2 ]
Wan, Ying [3 ]
Ji, Qing [4 ]
Fang, Yongfei [1 ]
Wu, Yuzhang [2 ]
机构：
[1] Third Mil Med Univ, Southwest Hosp, Dept Rheumatol, Chongqing 400038, Peoples R China
[2] Third Mil Med Univ, Inst Immunol, PLA, Chongqing 400038, Peoples R China
[3] Third Mil Med Univ, RNA Biol Lab, Biomed Anal Ctr, Chongqing 400038, Peoples R China
[4] Third Mil Med Univ, Southwest Hosp, Dept Digest Dis, Chongqing 400038, Peoples R China
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2013年 / 10卷 / 02期
基金：
中国国家自然科学基金;
关键词：
microRNA; B cell; development; function; INDUCED CYTIDINE DEAMINASE; NORMAL IMMUNE FUNCTION; RHEUMATOID-ARTHRITIS; HIGH EXPRESSION; SMALL RNAS; DIFFERENTIATION; LYMPHOMA; MICE; BIOGENESIS; GENERATION;
D O I：
10.1038/cmi.2012.62
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
MicroRNA (miRNA)-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved in normal immune functions and inflammation. In this review, we focus on recent advances that have elucidated the role of miRNAs in B-cell development, differentiation, apoptosis and function. While the regulatory mechanisms of miRNAs in controlling and maintaining B-cell fate remain largely uncharacterized, further studies on miRNAs and their targets will increase our understanding of B-cell development and function. Such studies may be able to provide new therapeutic strategies for treating autoimmune diseases. Cellular & Molecular Immunology (2013) 10, 107-112; doi: 10.1038/cmi.2012.62; published online 14 January 2013
引用
收藏
页码：107 / 112
页数：6
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