Clinical Management of Staphylococcus aureus Bacteremia in Neonates, Children, and Adolescents

被引：32

作者：

McMullan, Brendan J. ^{[1
,2
,3
]}

Campbell, Anita J. ^{[4
,5
,6
]}

Blyth, Christopher C. ^{[4
,5
,6
,7
]}

McNeil, J. Chase ^{[8
]}

Montgomery, Christopher P. ^{[9
,10
]}

Tong, Steven Y. C. ^{[11
,12
,13
]}

Bowen, Asha C. ^{[4
,5
,6
,11
,14
]}

机构：

[1] Sydney Childrens Hosp, Dept Immunol & Infect Dis, Randwick, NSW, Australia

[2] Univ New South Wales, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

[3] Univ Melbourne, Natl Ctr Infect Canc, Melbourne, Vic, Australia

[4] Perth Childrens Hosp, Dept Infect Dis, 15 Hosp Ave, Nedlands, WA 6009, Australia

[5] Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Nedlands, WA, Australia

[6] Univ Western Australia, Sch Med, Perth, WA, Australia

[7] QEII Med Ctr, Dept Microbiol, Path West Lab Med, Nedlands, WA, Australia

[8] Baylor Coll Med, Dept Pediat, Sect Infect Dis, Houston, TX 77030 USA

[9] Nationwide Childrens Hosp, Ctr Microbial Pathogenesis, Abigail Wexner Res Inst, Columbus, OH USA

[10] Ohio State Univ, Dept Pediat, Div Crit Care, Columbus, OH 43210 USA

[11] Menzies Sch Hlth Res, Darwin, NT, Australia

[12] Royal Melbourne Hosp, Victorian Infect Dis Serv, Melbourne, Vic, Australia

[13] Univ Melbourne, Doherty Dept, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia

[14] Univ Notre Dame Australia, Fremantle, WA, Australia

来源：

PEDIATRICS | 2020年 / 146卷 / 03期

基金：

英国医学研究理事会;

关键词：

INFECTIOUS-DISEASES SOCIETY; BLOOD-STREAM INFECTIONS; METHICILLIN-RESISTANT; TROUGH CONCENTRATION; CEFTAROLINE FOSAMIL; PRACTICE GUIDELINES; VANCOMYCIN; ENDOCARDITIS; THERAPY; COMPLICATIONS;

D O I：

10.1542/peds.2020-0134

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We systematically appraised the available literature, summarizing SAB management in children for key clinical questions.Staphylococcus aureus is a common cause of community and health care-associated bacteremia, with authors of recent studies estimating the incidence of S aureus bacteremia (SAB) in high-income countries between 8 and 26 per 100000 children per year. Despite this, <300 children worldwide have ever been randomly assigned into clinical trials to assess the efficacy of treatment of SAB. A panel of infectious diseases physicians with clinical and research interests in pediatric SAB identified 7 key clinical questions. The available literature is systematically appraised, summarizing SAB management in children in relation to these priority clinical questions. The management of neonates, children, and adolescents with SAB is predominantly based on clinical experience and trial data extrapolated from adult studies, with limited high-quality evidence available to guide management. The optimal, comprehensive management strategies for SAB in children will remain unknown until the questions outlined are answered through prospective observational cohorts and inclusion of children with SAB in clinical trials.

引用

页数：13

共 74 条

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