Santonin-Related Compound 2 Inhibits the Nuclear Trans location of NF-κB Subunit p65 by Targeting Cysteine 38 in TNF-α-Induced NF-κB Signaling Pathway

被引：15

作者：

Tamura, Ryuichi ^{[1
]}

Morimoto, Kyoko ^{[1
]}

Hirano, Seiya ^{[1
]}

Wang, Liyan ^{[2
]}

Zhao, Ming ^{[2
]}

Ando, Masayoshi ^{[3
]}

Kataoka, Takao ^{[1
]}

机构：

[1] Kyoto Inst Technol, Dept Appl Biol, Sakyo Ku, Kyoto 6068585, Japan

[2] Niigata Univ, Grad Sch Sci & Technol, Nishi Ku, Niigata 9502181, Japan

[3] Niigata Univ, Dept Chem & Chem Engn, Nishi Ku, Niigata 9502181, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 12期

关键词：

eudesmane; nuclear factor kappa B; santonin-related compound 2; sesquiterpene lactone; tumor necrosis factor alpha; SESQUITERPENE LACTONES; ACTIVATION; IMMUNITY; BINDING;

D O I：

10.1271/bbb.120619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(11S)-2 alpha-Bromo-3-oxoeudesmano-12,6 alpha-lactone, designated santonin-related compound 2 (SRC2), only weakly affected I kappa B alpha degradation after tumor necrosis factor-alpha (TNF-alpha) stimulation, but strongly blocked the nuclear translocation of nuclear factor kappa B (NF-kappa B) subunit p65. Replacement of Cys-38 of p65 with serine abolished the inhibitory effect of SRC2 on this TNF-alpha-induced nuclear translocation. These results indicate that SRC2 inhibits the nuclear translocation of p65 by targeting Cys-38.

引用

页码：2360 / 2363

页数：4

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