Potential role of renal sympathetic denervation for the treatment of cardiac arrhythmias

被引：16

作者：

Ukena, Christian ^{[1
]}

Mahfoud, Felix ^{[1
]}

Linz, Dominik ^{[1
]}

Boehm, Michael ^{[1
]}

Neuberger, Hans-Ruprecht ^{[1
]}

机构：

[1] Univ Klinikurn Saarlandes, Klin Innere Med Kardiol Angiol & Internist Intens, D-66421 Homburg, Germany

来源：

EUROINTERVENTION | 2013年 / 9卷

关键词：

atrial fibrillation; autonomic nervous system; electric storm; heart rate; OBSTRUCTIVE SLEEP-APNEA; ATRIAL-FIBRILLATION; RESISTANT HYPERTENSION; ELECTRICAL STORM; EUROPEAN-SOCIETY; NERVOUS-SYSTEM; BLOOD-PRESSURE; TASK-FORCE; MANAGEMENT; ABLATION;

D O I：

10.4244/EIJV9SRA19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The autonomic nervous system (ANS) has a pivotal role in the pathogenesis and maintenance of atrial and ventricular arrhythmias. Catheter-based renal denervation (RDN) is associated with a reduction of central sympathetic activity, muscle sympathetic nerve activity, and blood pressure in resistant hypertension. As renal afferent nerves are regulators of central sympathetic tone, RDN opens the possibility to modulate sympathetic activity, but without affecting peripheral chemoreceptors and mechanoreceptors in the heart and other organs. RDN was shown to reduce heart rate in humans and to reduce inducibility of atrial fibrillation (AF) as well as ventricular rate during AF in experimental studies. First evidence indicates that pulmonary vein isolation in combination with RDN increases the rate of AF freedom in patients with resistant hypertension. Furthermore, RDN may have a beneficial impact on ventricular arrhythmia, in particular in patients with coronary artery disease or heart failure.

引用

页码：R110 / R116

页数：7

共 60 条

[1]

Ahmed H, 2013, J CARDIOVASC ELECTRO

[2] Renal Sympathetic Denervation Using an Irrigated Radiofrequency Ablation Catheter for the Management of Drug-Resistant Hypertension [J].

Ahmed, Humera ;

Neuzil, Petr ;

Skoda, Jan ;

Petru, Jan ;

Sediva, Lucie ;

Schejbalova, Marcela ;

Reddy, Vivek Y. .

JACC-CARDIOVASCULAR INTERVENTIONS, 2012, 5 (07) :758-765

[3] Bilateral Cardiac Sympathetic Denervation for the Management of Electrical Storm [J].

Ajijola, Olujimi A. ;

Lellouche, Nicholas ;

Bourke, Tara ;

Tung, Roderick ;

Ahn, Samuel ;

Mahajan, Aman ;

Shivkumar, Kalyanam .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (01) :91-92

[4]

[Anonymous], INT J CARDIOL

[5] Cardiac Ablation and Renal Denervation Systems Have Distinct Purposes and Different Technical Requirements [J].

Blessing, Erwin ;

Esler, Murray D. ;

Francis, Darrel P. ;

Schmieder, Roland E. .

JACC-CARDIOVASCULAR INTERVENTIONS, 2013, 6 (03) :314-314

[6]

Böhm M, 2010, LANCET, V376, P886, DOI 10.1016/S0140-6736(10)61259-7

[7] Renal Sympathetic Denervation Reduces Left Ventricular Hypertrophy and Improves Cardiac Function in Patients With Resistant Hypertension [J].

Brandt, Mathias C. ;

Mahfoud, Felix ;

Reda, Sara ;

Schirmer, Stephan H. ;

Erdmann, Erland ;

Boehm, Michael ;

Hoppe, Uta C. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (10) :901-909

[8]

Calkins H, 2012, HEART RHYTHM, V9, P632, DOI 10.1016/j.hrthm.2011.12.016

[9]

Camm AJ, 2010, EUROPACE, V12, P1360, DOI [10.1093/europace/euq350, 10.1093/eurheartj/ehq278]

[10] Relationship between regional cardiac hyperinnervation and ventricular arrhythmia [J].

Cao, JM ;

Fishbein, MC ;

Han, JB ;

Lai, WW ;

Lai, AC ;

Wu, TJ ;

Czer, L ;

Wolf, PL ;

Denton, TA ;

Shintaku, IP ;

Chen, PS ;

Chen, LS .

CIRCULATION, 2000, 101 (16) :1960-1969

← 1 2 3 4 5 6 →