Neonectrolide A, a New Oxaphenalenone Spiroketal from the Fungus Neonectria sp.

被引：36

作者：

Ren, Jinwei ^{[1
]}

Zhang, Fan ^{[1
]}

Liu, Xiangyu ^{[2
]}

Li, Li ^{[3
,4
]}

Liu, Gang ^{[1
]}

Liu, Xingzhong ^{[1
]}

Che, Yongsheng ^{[5
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100190, Peoples R China

[2] Huazhong Agr Univ, Coll Resources & Environm, Wuhan 430070, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100050, Peoples R China

[5] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 24期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

ELECTRONIC CIRCULAR-DICHROISM; ENDOLICHENIC FUNGUS; DERIVATIVES; DIMERS; ACID;

D O I：

10.1021/ol302979f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Neonectrolide A (1), an oxaphenalenone spiroketal with the previously undescribed (5,8'-dimethyl-5'-oxo-3a',4,5,5'-tetrahydro-3H,3'H-spiro[furan-2,2'-isochromeno[3,4,5-def]chromene]-3'yl)but-3-enoic acid skeleton, was isolated from cultures of the fungus Neonectria sp. Its absolute configuration was assigned by electronic circular dichroism (ECD) calculations. The skeleton of an oxaphenalenone fused with a 1,6-dioxaspiro[4.5]decane moiety in 1 could be derived from the coisolated putative precursors, corymbiferan lactone E (2) and 3-dehydroxy-4-O-acetylcephalosporolide C (3).

引用

页码：6226 / 6229

页数：4

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