VIM-2-producing Multidrug-Resistant Pseudomonas aeruginosa ST175 Clone, Spain

被引：64
作者：
Viedma, Esther
Juan, Carlos [2 ]
Villa, Jennifer
Barrado, Laura
Orellana, M. Angeles
Sanz, Francisca
Otero, Joaquin R.
Oliver, Antonio [2 ]
Chaves, Fernando [1 ]
机构：
[1] Hosp Univ 12 Octubre, Serv Microbiol Clin, Madrid 28041, Spain
[2] Hosp Univ Son Espases, Palma de Mallorca, Spain
来源：
EMERGING INFECTIOUS DISEASES | 2012年 / 18卷 / 08期
关键词：
METALLO-BETA-LACTAMASE; INTEGRON-BORNE GENE; NOSOCOMIAL OUTBREAK; ANTIMICROBIAL RESISTANCE; CARBAPENEM RESISTANCE; CLINICAL ISOLATE; VIM-2; MECHANISMS; SUSCEPTIBILITY; IDENTIFICATION;
D O I：
10.3201/eid1808.111234
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the b/a(VIM-2) gene in all but 1 isolate, which harbored b/a(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P aeruginosa nosocomial infections.
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页码：1235 / 1241
页数：7
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