Changes in the Expression of Transcription Factor Oct4 during Postnatal Development of Adrenal Medulla

被引：2
|
作者：
Yaglova, N., V [1 ]
Obernikhin, S. S. [1 ]
Nazimova, S., V [1 ]
Timokhina, E. P. [1 ]
Yaglov, V. V. [1 ]
机构：
[1] AP Petrovsky Russian Res Ctr Surg, AP Avtsyn Res Inst Human Morphol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 173卷 / 06期
关键词：
Oct4; chromaffin cells; medulla; adrenal gland; development; SENSITIVE MARKER;
D O I：
10.1007/s10517-022-05631-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We analyzed the expression of the transcription factor Oct4 in the chromaffin cells during the postnatal development of the adrenal glands in rats. Single Oct4(+)-chromaffin cells with nuclear localization of the protein were found in the medulla, and their number increased in parallel with a decrease in the proliferative activity of cells. In postnatal development, 100% of chromaffin cells demonstrated high expression of tyrosine hydroxylase, which attested to their differentiation and functional activity. It was found that all Oct4(+) cells were differentiated chromaffin cells. An increase in the pool of Oct4-expressing cells after the completion of organ growth suggests the formation of a potential source for the physiological and reparative regeneration of the adrenal medulla.
引用
收藏
页码：783 / 786
页数：4
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