Assessment of Luminal and Basal Phenotypes in Bladder Cancer

被引：115

作者：

Guo, Charles C. ^{[1
]}

Bondaruk, Jolanta ^{[1
]}

Yao, Hui ^{[2
]}

Wang, Ziqiao ^{[3
]}

Zhang, Li ^{[4
]}

Lee, Sangkyou ^{[1
]}

Lee, June-Goo ^{[1
]}

Cogdell, David ^{[1
]}

Zhang, Miao ^{[1
]}

Yang, Guoliang ^{[1
]}

Dadhania, Vipulkumar ^{[1
]}

Choi, Woonyoung ^{[5
]}

Wei, Peng ^{[3
]}

Gao, Jianjun ^{[6
]}

Theodorescu, Dan ^{[7
]}

Logothetis, Christopher ^{[6
]}

Dinney, Colin ^{[8
]}

Kimmel, Marek ^{[9
]}

Weinstein, John N. ^{[2
]}

McConkey, David J. ^{[5
]}

Czerniak, Bogdan ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[4] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA

[5] Johns Hopkins Univ, Johns Hopkins Greenberg Bladder Canc Inst, Baltimore, MD USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA

[7] Cedars Sinai, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA

[9] Rice Univ, Dept Stat, Houston, TX 77251 USA

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

GENE-EXPRESSION; MOLECULAR SUBTYPES; NEOADJUVANT CHEMOTHERAPY; UROTHELIAL CARCINOMA; PREDICTING RESPONSE; CLASSIFICATION; SIGNATURE; CISPLATIN; IDENTIFICATION; METHOTREXATE;

D O I：

10.1038/s41598-020-66747-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genomic profiling studies have demonstrated that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to frontline chemotherapy. We analyzed the mRNA expressions of signature luminal and basal genes in bladder cancer tumor samples from publicly available and MD Anderson Cancer Center cohorts. We developed a quantitative classifier referred to as basal to luminal transition (BLT) score which identified the molecular subtypes of bladder cancer with 80-94% sensitivity and 83-93% specificity. In order to facilitate molecular subtyping of bladder cancer in primary care centers, we analyzed the protein expressions of signature luminal (GATA3) and basal (KRT5/6) markers by immunohistochemistry, which identified molecular subtypes in over 80% of the cases. In conclusion, we provide a tool for assessment of molecular subtypes of bladder cancer in routine clinical practice.

引用

页数：14

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