Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

被引：69

作者：

Hoque, Jiaul ^{[1
]}

Konai, Mohini M. ^{[1
]}

Samaddar, Sandip ^{[1
]}

Gonuguntala, Spandhana ^{[1
]}

Manjunath, Goutham B. ^{[1
]}

Ghosh, Chandradhish ^{[1
]}

Haldar, Jayanta ^{[1
]}

机构：

[1] Jawaharlal Nehru Ctr Adv Sci Res, New Chem Unit, Chem Biol & Med Chem Lab, Jakkur 560064, Bengaluru, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 71期

关键词：

PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL PEPTIDES; PERSISTENT INFECTIONS; PEPTOID MIMICS; MEMBRANE; LIPOPEPTIDES; MECHANISM; POTENT; OLIGOMERS; POLYMERS;

D O I：

10.1039/c5cc05159b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this class of membran-active molecules disarms the development of bacterial resistance.

引用

页码：13670 / 13673

页数：4

共 30 条

[1] Molecular mechanisms of antibacterial multidrug resistance
Alekshun, Michael N.
Levy, Stuart B.
[J]. CELL, 2007, 128 (06) : 1037 - 1050
[2] In Vitro and In Vivo Activities of Novel Cyclic Lipopeptides Against Staphylococcal Biofilms
Bionda, Nina
Pastar, Irena
Davis, Stephen C.
Cudic, Predrag
[J]. PROTEIN AND PEPTIDE LETTERS, 2014, 21 (04) : 352 - 356
[3] Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
Chongsiriwatana, Nathaniel P.
Patch, James A.
Czyzewski, Ann M.
Dohm, Michelle T.
Ivankin, Andrey
Gidalevitz, David
Zuckermann, Ronald N.
Barron, Annelise E.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (08) : 2794 - 2799
[4] Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides
Chongsiriwatana, Nathaniel P.
Miller, Tyler M.
Wetzler, Modi
Vakulenko, Sergei
Karlsson, Amy J.
Palecek, Sean P.
Mobashery, Shahriar
Barron, Annelise E.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (01) : 417 - 420
[5] Bacterial biofilms: A common cause of persistent infections
Costerton, JW
Stewart, PS
Greenberg, EP
[J]. SCIENCE, 1999, 284 (5418) : 1318 - 1322
[6] Understanding biofilm resistance to antibacterial agents
Davies, D
[J]. NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (02) : 114 - 122
[7] Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!
Ghosh, Chandradhish
Manjunath, Goutham B.
Akkapeddi, Padma
Yarlagadda, Venkateswarlu
Hoque, Jiaul
Uppu, Divakara S. S. M.
Konai, Mohini M.
Haldar, Jayanta
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (04) : 1428 - 1436
[8] Foldamers as versatile frameworks for the design and evolution of function
Goodman, Catherine M.
Choi, Sungwook
Shandler, Scott
DeGrado, William F.
[J]. NATURE CHEMICAL BIOLOGY, 2007, 3 (05) : 252 - 262
[9] Polymeric coatings that inactivate both influenza virus and pathogenic bacteria
Haldar, Jayanta
An, Deqiang
de Cienfuegos, Luis Alvarez
Chen, Jianzhu
Klibanov, Alexander M.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (47) : 17667 - 17671
[10] Bacterial biofilms: From the natural environment to infectious diseases
Hall-Stoodley, L
Costerton, JW
Stoodley, P
[J]. NATURE REVIEWS MICROBIOLOGY, 2004, 2 (02) : 95 - 108

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