Vitamin D, aging, and cancer

被引：22

作者：

Tuohimaa, Pentti ^{[1
,2
]}

机构：

[1] Univ Tampere, Sch Med, Dept Anat, Tampere 33014, Finland

[2] Tampere Univ Hosp, Dept Med Chem, Tampere, Finland

来源：

NUTRITION REVIEWS | 2008年 / 66卷 / 10期

关键词：

aging; calcidiol; cancer; chronic diseases; sun exposure; vitamin D3;

D O I：

10.1111/j.1753-4887.2008.00095.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Deficiency of the prohormone calcidiol (25OH vitamin D-3) seems to be associated with several aging-related chronic diseases including cancer. Our results suggest that calcidiol is mainly responsible for differentiation homeostasis, whereas calcitriol might be more involved in calcium homeostasis. Therefore, an imbalance of calcidiol rather than calcitriol is a risk factor for cancer and chronic diseases. Calcidiol insufficiency, as well as insufficient solar exposure, is associated with increased risk of several solid cancers. Both a vitamin D-3 deficiency and a high concentration of calcidiol may increase cancer risk. Similarly, aging phenomena show a U-shaped association with vitamin D bioactivity. Therefore, the chronic diseases and cancers related to aging might be prevented by an optimal concentration of serum calcidiol, which remains to be determined. (C) 2008 International Life Sciences Institute.

引用

页码：S147 / S152

页数：6

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