The Pathophysiology of Respiratory Failure: Control of Breathing, Respiratory Load, and Muscle Capacity

被引：17
作者：
Adler, Dan
Janssens, Jean-Paul
机构：
[1] Univ Hosp Geneva, Div Lung Dis, Geneva, Switzerland
[2] Geneva Sch Med, Geneva, Switzerland
来源：
RESPIRATION | 2019年 / 97卷 / 02期
关键词：
Respiratory failure; Control of breathing; Respiratory load; Muscle function; Noninvasive ventilation; OBESITY-HYPOVENTILATION SYNDROME; NASAL INSPIRATORY PRESSURE; AMYOTROPHIC-LATERAL-SCLEROSIS; PATIENT-VENTILATOR ASYNCHRONY; TERM NONINVASIVE VENTILATION; RANDOMIZED CONTROLLED-TRIAL; ELECTROENCEPHALOGRAPHIC EVIDENCE; CORTEX ACTIVATION; CORTICAL DRIVE; VITAL CAPACITY;
D O I：
10.1159/000494063
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The purpose of this review is to provide an overview on how interactions between control of breathing, respiratory load, and muscle function may lead to respiratory failure. The mechanisms involved vary according to the underlying pathology, but respiratory failure is most often the result of an imbalance between the muscular pump and the mechanical load placed upon it. Changes in respiratory drive and response to CO2 seem to be important contributors to the pathophysiology of respiratory failure. Inspiratory muscle dysfunction is also frequent but is not a mandatory prerequisite to respiratory failure since increased load may also be sufficient to precipitate it. It is crucial to recognize these interactions to be able to timeously establish patients on mechanical ventilation and adapt the ventilator settings to their respiratory system physiology. (C) 2018 S. Karger AG, Basel
引用
收藏
页码：93 / 104
页数：12
相关论文
共 78 条
[1]   Validity of transcutaneous PCO2 in monitoring chronic hypoventilation treated with non-invasive ventilation [J].
Aarrestad, Sigurd ;
Tollefsen, Elin ;
Kleiven, Anne Louise ;
Qvarfort, Magnus ;
Janssens, Jean-Paul ;
Skjonsberg, Ole Henning .
RESPIRATORY MEDICINE, 2016, 112 :112-118
[2]  
Adler D, 2017, EUR RESP J S61, V50
[3]   Comorbidities and Subgroups of Patients Surviving Severe Acute Hypercapnic Respiratory Failure in the Intensive Care Unit [J].
Adler, Dan ;
Pepin, Jean-Louis ;
Dupuis-Lozeron, Elise ;
Espa-Cervena, Katerina ;
Merlet-Violet, Roselyne ;
Muller, Hajo ;
Janssens, Jean-Paul ;
Brochard, Laurent .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 196 (02) :200-207
[4]   Does Inspiratory Muscle Dysfunction Predict Readmission after Intensive Care Unit Discharge? [J].
Adler, Dan ;
Dupuis-Lozeron, Elise ;
Richard, Jean-Christophe ;
Janssens, Jean-Paul ;
Brochard, Laurent .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 190 (03) :347-350
[5]   Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness [J].
Adler, Dan ;
Perrig, Stephen ;
Takahashi, Hiromitsu ;
Espa, Fabrice ;
Rodenstein, Daniel ;
Pepin, Jean Louis ;
Janssens, Jean-Paul .
SLEEP AND BREATHING, 2012, 16 (04) :1081-1090
[6]   Electrophysiologic techniques for the assessment of respiratory muscle function [J].
Aldrich, TK ;
Sinderby, C ;
McKenzie, DK ;
Estenne, M ;
Gandevia, SC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (04) :548-+
[7]  
ALLEN SM, 1985, BRIT J DIS CHEST, V79, P267, DOI 10.1016/S0007-0971(85)80029-2
[8]   Mechanisms underlying effects of nocturnal ventilation on daytime blood gases in neuromuscular diseases [J].
Annane, D ;
Quera-Salva, MA ;
Lofaso, F ;
Vercken, JB ;
Lesieur, O ;
Fromageot, C ;
Clair, B ;
Gajdos, P ;
Raphael, JC .
EUROPEAN RESPIRATORY JOURNAL, 1999, 13 (01) :157-162
[9]  
[Anonymous], 1999, CHEST, V116, P521
[10]   Hypercapnia and ventilatory periodicity in obstructive sleep apnea syndrome [J].
Ayappa, I ;
Berger, KI ;
Norman, RG ;
Oppenheimer, BW ;
Rapoport, DM ;
Goldring, RM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (08) :1112-1115
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