AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV

被引：114

作者：

Bhatt, Aadra P. ^{[1
,2
]}

Damania, Blossom ^{[1
,2
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 3卷

关键词：

Akt; KSHV; mTOR; PI3K; B cells; SARCOMA-ASSOCIATED-HERPESVIRUS; PROTEIN-COUPLED-RECEPTOR; PRIMARY EFFUSION LYMPHOMA; NF-KAPPA-B; MULTICENTRIC CASTLEMANS-DISEASE; PRIMARY ENDOTHELIAL-CELLS; FOCAL ADHESION KINASE; RIBOSOMAL S6 KINASE; KAPOSIS-SARCOMA; NUCLEAR ANTIGEN;

D O I：

10.3389/fimmu.2012.00401

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As an obligate intracellular parasite, Kaposi sarcoma-associated herpesvirus (KSHV) relies on the host cell machinery to meet its needs for survival, viral replication, production, and dissemination of progeny virions. KSHV is a gammaherpesvirus that is associated with three different malignancies: Kaposi sarcoma (KS), and two B cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease. KSHV viral proteins modulate the cellular phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway, which is a ubiquitous pathway that also controls B lymphocyte proliferation and development. We review the mechanisms by which KSHV manipulates the PI3K/AKT/mTOR pathway, with a specific focus on B cells.

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页数：16

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共 186 条

[81] Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): Role of heparan sulfate, DC-SIGN, integrins and signaling [J].

Kerur, Nagaraj ;

Veettil, Mohanan Valiya ;

Sharma-Walia, Neelam ;

Sadagopan, Sathish ;

Bottero, Virginie ;

Paul, Arun George ;

Chandran, Bala .

VIROLOGY, 2010, 406 (01) :103-116

[82] Persistent infection of Epstein-Barr virus-positive B lymphocytes by human herpesvirus 8 [J].

Kliche, S ;

Kremmer, E ;

Hammerschmidt, W ;

Koszinowski, U ;

Haas, J .

JOURNAL OF VIROLOGY, 1998, 72 (10) :8143-8149

[83] The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter [J].

Knight, JS ;

Cotter, MA ;

Robertson, ES .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) :22971-22978

[84] THE ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE BY RAS [J].

KODAKI, T ;

WOSCHOLSKI, R ;

HALLBERG, B ;

RODRIGUEZVICIANA, P ;

DOWNWARD, L ;

PARKER, PJ .

CURRENT BIOLOGY, 1994, 4 (09) :798-806

[85] Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells [J].

Krishnan, HH ;

Sharma-Walia, N ;

Streblow, DN ;

Naranatt, PP ;

Chandran, B .

JOURNAL OF VIROLOGY, 2006, 80 (03) :1167-1180

[86] Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression [J].

Krishnan, HH ;

Naranatt, PP ;

Smith, MS ;

Zeng, L ;

Bloomer, C ;

Chandran, B .

JOURNAL OF VIROLOGY, 2004, 78 (07) :3601-3620

[87] Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replication [J].

Kuang, Ersheng ;

Tang, Qiyi ;

Maul, Gerd G. ;

Zhu, Fanxiu .

JOURNAL OF VIROLOGY, 2008, 82 (04) :1838-1850

[88] Mechanism of Sustained Activation of Ribosomal S6 Kinase (RSK) and ERK by Kaposi Sarcoma-associated Herpesvirus ORF45 MULTIPROTEIN COMPLEXES RETAIN ACTIVE PHOSPHORYLATED ERK AND RSK AND PROTECT THEM FROM DEPHOSPHORYLATION [J].

Kuang, Ersheng ;

Wu, Fayi ;

Zhu, Fanxiu .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (20) :13958-13968

[89] The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) [J].

Lagunoff, M ;

Ganem, D .

VIROLOGY, 1997, 236 (01) :147-154

[90] Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus [J].

Lagunoff, M ;

Majeti, R ;

Weiss, A ;

Ganem, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) :5704-5709

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