Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models

被引:57
作者
Alvarez-Satta, Maria [1 ,2 ]
Berna-Erro, Alejandro [1 ]
Carrasco-Garcia, Estefania [1 ,2 ]
Alberro, Ainhoa [3 ]
Saenz-Antonanzas, Ander [1 ]
Vergara, Itziar [4 ,5 ]
Otaegui, David [3 ,6 ]
Matheu, Ander [1 ,2 ,7 ]
机构
[1] Biodonostia Hlth Res Inst, Grp Cellular Oncol, San Sebastian, Spain
[2] CIBER Frailty & Hlth Aging CIBERfes, San Sebastian, Spain
[3] Biodonostia Hlth Res Inst, Grp Multiple Sclerosis, San Sebastian, Spain
[4] Biodonostia Hlth Res Inst, Grp Primary Hlth, San Sebastian, Spain
[5] Hlth Serv Res Chron Patients Network REDISSEC, San Sebastian, Spain
[6] Spanish Network Multiple Sclerosis, San Sebastian, Spain
[7] Basque Fdn, Ikerbasque, Bilbao, Spain
来源
AGING-US | 2020年 / 12卷 / 10期
关键词
frailty; aging; biomarker; oxidative stress; inflammation; DWELLING OLDER PERSONS; COGNITIVE FRAILTY; GERIATRIC SYNDROME; PROTEIN DAMAGE; AGING MICE; POPULATION; DISABILITY; DEFINITION; BIOMARKERS; CONSENSUS;
D O I
10.18632/aging.103295
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Frailty represents a state of vulnerability and increases the risk of negative health outcomes, which is becoming an important public health problem. Over recent years, multiple independent studies have attempted to identify biomarkers that can predict, diagnose, and monitor frailty at the biological level. Among them, several promising candidates have been associated with frailty status including antioxidants and free radicals, and also inflammatory response biomarkers. In this review, we will summarize the more recent advances in this field. Moreover, the identification of scales and measurements to detect and quantify frailty in aged mice, as well as the generation of mouse models, have started to unravel the underlying biological and molecular mechanisms of frailty. We will discuss them here with an emphasis on murine models with overexpression of glucose-6-phosphate dehydrogenase and loss of function of superoxide dismutase and interleukin 10, which reveal that altered oxidative stress and inflammation pathways are involved in the physiopathology of frailty. In summary, we provide the current available evidence, from both human cohorts and experimental animal models, that highlights oxidative damage and inflammation as relevant biomarkers and drivers of frailty.
引用
收藏
页码:9982 / 9999
页数:18
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