Dabigatran in patients with atrial fibrillation: perioperative and periinterventional management

被引:14
作者
Weltermann, A. [1 ]
Brodmann, M. [2 ]
Domanovits, H. [3 ]
Eber, B. [4 ]
Gottsauner-Wolf, M. [5 ]
Halbmayer, W. M. [6 ]
Hiesmayr, J. M. [7 ]
Kyrle, P. A. [8 ]
Laengle, F. [9 ]
Roithinger, F. X. [10 ]
Watzke, H. [8 ]
Windhager, R. [11 ]
Wolf, C. [12 ]
Zweiker, R. [13 ]
机构
[1] Elisabethinen Hosp Linz, Dept Med 1, A-4020 Linz, Austria
[2] Med Univ Graz, Div Angiol, Dept Internal Med, Graz, Austria
[3] Med Univ Vienna, Dept Emergency Med, Vienna, Austria
[4] Clin Wels Grieskirchen, Div Cardiol, Dept Internal Med 2, Wels, Austria
[5] Med Univ Vienna, Div Cardiol, Dept Internal Med 2, Vienna, Austria
[6] Municipal Hosp Hietzing Rosenhugel, Inst Lab Med, Vienna, Austria
[7] Med Univ Vienna, Dept Cardiothorac & Vasc Anaesthesia & Crit Care, Vienna, Austria
[8] Med Univ Vienna, Dept Internal Med 1, Vienna, Austria
[9] Landesklinikum Wiener Neustadt, Dept Surg, Wiener Neustadt, Austria
[10] Landesklinikum Thermenreg Modling, Dept Internal Med, Modling, Austria
[11] Med Univ Vienna, Dept Orthopaed, Vienna, Austria
[12] Donauspital, Dept Cardiol, Sozialmed Zentrum Ost, Vienna, Austria
[13] Med Univ Graz, Div Cardiol, Dept Internal Med, Graz, Austria
关键词
Dabigatran; Bridging; Surgery; Endoscopy; Bleeding; VENOUS THROMBOEMBOLISM; ANTIPLATELET THERAPY; ETEXILATE; PHARMACODYNAMICS; PHARMACOKINETICS; ANTICOAGULANT; REPLACEMENT; PREVENTION; ENOXAPARIN; GUIDELINE;
D O I
10.1007/s00508-012-0166-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In any type of invasive surgery, the patient's individual risk of thromboembolism has to be weighed against the risk of bleeding. Based on various everyday situations in clinical routine, the purpose of the present expert recommendations is to provide appropriate perioperative and periinterventional management for patients with atrial fibrillation undergoing long-term treatment with the thrombin inhibitor dabigatran. As we currently have no routine laboratory test to measure therapeutic levels of the substance or the risk of bleeding, general measures such as a standardized documentation of the patient's history, a sufficient time interval between the last preoperative dose and the procedure, and careful control of local hemostasis should be given special attention.
引用
收藏
页码:340 / 347
页数:8
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