Dabigatran in patients with atrial fibrillation: perioperative and periinterventional management

被引：14

作者：

Weltermann, A. ^{[1
]}

Brodmann, M. ^{[2
]}

Domanovits, H. ^{[3
]}

Eber, B. ^{[4
]}

Gottsauner-Wolf, M. ^{[5
]}

Halbmayer, W. M. ^{[6
]}

Hiesmayr, J. M. ^{[7
]}

Kyrle, P. A. ^{[8
]}

Laengle, F. ^{[9
]}

Roithinger, F. X. ^{[10
]}

Watzke, H. ^{[8
]}

Windhager, R. ^{[11
]}

Wolf, C. ^{[12
]}

Zweiker, R. ^{[13
]}

机构：

[1] Elisabethinen Hosp Linz, Dept Med 1, A-4020 Linz, Austria

[2] Med Univ Graz, Div Angiol, Dept Internal Med, Graz, Austria

[3] Med Univ Vienna, Dept Emergency Med, Vienna, Austria

[4] Clin Wels Grieskirchen, Div Cardiol, Dept Internal Med 2, Wels, Austria

[5] Med Univ Vienna, Div Cardiol, Dept Internal Med 2, Vienna, Austria

[6] Municipal Hosp Hietzing Rosenhugel, Inst Lab Med, Vienna, Austria

[7] Med Univ Vienna, Dept Cardiothorac & Vasc Anaesthesia & Crit Care, Vienna, Austria

[8] Med Univ Vienna, Dept Internal Med 1, Vienna, Austria

[9] Landesklinikum Wiener Neustadt, Dept Surg, Wiener Neustadt, Austria

[10] Landesklinikum Thermenreg Modling, Dept Internal Med, Modling, Austria

[11] Med Univ Vienna, Dept Orthopaed, Vienna, Austria

[12] Donauspital, Dept Cardiol, Sozialmed Zentrum Ost, Vienna, Austria

[13] Med Univ Graz, Div Cardiol, Dept Internal Med, Graz, Austria

来源：

WIENER KLINISCHE WOCHENSCHRIFT | 2012年 / 124卷 / 9-10期

关键词：

Dabigatran; Bridging; Surgery; Endoscopy; Bleeding; VENOUS THROMBOEMBOLISM; ANTIPLATELET THERAPY; ETEXILATE; PHARMACODYNAMICS; PHARMACOKINETICS; ANTICOAGULANT; REPLACEMENT; PREVENTION; ENOXAPARIN; GUIDELINE;

D O I：

10.1007/s00508-012-0166-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In any type of invasive surgery, the patient's individual risk of thromboembolism has to be weighed against the risk of bleeding. Based on various everyday situations in clinical routine, the purpose of the present expert recommendations is to provide appropriate perioperative and periinterventional management for patients with atrial fibrillation undergoing long-term treatment with the thrombin inhibitor dabigatran. As we currently have no routine laboratory test to measure therapeutic levels of the substance or the risk of bleeding, general measures such as a standardized documentation of the patient's history, a sufficient time interval between the last preoperative dose and the procedure, and careful control of local hemostasis should be given special attention.

引用

页码：340 / 347

页数：8

共 20 条

[1] [Anonymous], 022512 US FOOD DRUG
[2] [Anonymous], NEUE OR ANT
[3] [Anonymous], 2010, REC GUID PROD
[4] [Anonymous], CMACHMP2034682011
[5] Dabigatran versus Warfarin in Patients with Atrial Fibrillation.
Connolly, Stuart J.
Ezekowitz, Michael D.
Yusuf, Salim
Eikelboom, John
Oldgren, Jonas
Parekh, Amit
Pogue, Janice
Reilly, Paul A.
Themeles, Ellison
Varrone, Jeanne
Wang, Susan
Alings, Marco
Xavier, Denis
Zhu, Jun
Diaz, Rafael
Lewis, Basil S.
Darius, Harald
Diener, Hans-Christoph
Joyner, Campbell D.
Wallentin, Lars
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (12) : 1139 - 1151
[6] Acutely Injured Patients on Dabigatran
Cotton, Bryan A.
McCarthy, James J.
Holcomb, John B.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (21) : 2039 - 2040
[7] The perioperative management of antithrombotic therapy
Douketis, James. D.
Berger, Peter B.
Dunn, Andrew S.
Jaffer, Amir K.
Spyropoulos, Alex C.
Becker, Richard C.
Ansell, Jack
[J]. CHEST, 2008, 133 (06) : 299S - 339S
[8] Douketis JD, 2010, CURR PHARM DESIGN, V16, P3436
[9] Guideline on the management of anticoagulation and antiplatelet therapy for endoscopic procedures
Eisen, GM
Baron, TH
Dominitz, JA
Faigel, DO
Goldstein, JL
Johanson, JF
Mallery, JS
Raddawi, HM
Vargo, JJ
Waring, JP
Fanelli, RD
Wheeler-Harbough, J
[J]. GASTROINTESTINAL ENDOSCOPY, 2002, 55 (07) : 775 - 779
[10] Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement:: the RE-MODEL randomized trial
Eriksson, B. I.
Dahl, O. E.
Rosencher, N.
Kurth, A. A.
Van Dijk, N.
Frostick, S. P.
Kalebo, P.
Christiansen, A. V.
Hantel, S.
Hettiarachchi, R.
Schnee, J.
Buller, H. R.
[J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (11) : 2178 - 2185

← 1 2 →