Phenylethyl cinnamides:: A new series of α-glucosidase inhibitors from the leaves of Aegle marmelos

被引：42

作者：

Phuwapraisirisan, Preecha ^{[1
]}

Puksasook, Thanchanok ^{[1
,2
]}

Jong-Aramruang, Jonkolnee ^{[3
]}

Kokpol, Udom ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Nat Prod Res Unit, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Sci, Program Biotechnol, Bangkok 10330, Thailand

[3] Burapha Univ, Dept Chem, Fac Sci, Chon Buri 20231, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 18期

关键词：

phenylethyl cinnamide; Aegle marmelos; anhydromarmeline; aegelinosides A; aegelinosides B; alpha-glucosidase; diabetes mellitus;

D O I：

10.1016/j.bmcl.2008.08.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline (1), aegelinosides A (7) and B (8), were isolated from Aegle marmelos leaves as a-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline (2) revealed the most potent inhibitory effect against a-glucosidase with IC50 value of 35.8 mu M. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4956 / 4958

页数：3

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