Sarcopenia in the elderly: Basic and clinical issues

被引：130

作者：

Wang, Cuiying ^{[1
]}

Bai, Li ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Friendship Hosp, Med Hlth Ctr, Beijing 100050, Peoples R China

来源：

GERIATRICS & GERONTOLOGY INTERNATIONAL | 2012年 / 12卷 / 03期

关键词：

geriatrics; muscle; sarcopenia; MUSCLE PROTEIN-SYNTHESIS; DIFFERENT FIBER TYPES; HUMAN GROWTH-HORMONE; FAT-FREE MASS; SKELETAL-MUSCLE; RESISTANCE EXERCISE; BODY-COMPOSITION; OLDER MEN; MUSCULAR STRENGTH; CARDIAC CACHEXIA;

D O I：

10.1111/j.1447-0594.2012.00851.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The original definition of sarcopenia refers to the age-related loss of muscle mass. The literature suggests that the prevalence of sarcopenia in 60- to 70-year-olds is in the range of 513%. Prevalence estimates increase to 1150% for the population aged 80 years or older. Estimates by the World Health Organization suggest that there were 600 million people aged 60 years or older in the year 2000, and that this number will increase to 1.2 billion by the year 2025. There are, however, limited published data on serial measures of muscle mass in older subjects to establish the age-related changes in muscle mass and to relate this change with adverse health consequences. This review is focused on the definition, prevalence, symptoms, pharmacy and physical therapy of sarcopenia in older subjects with the aim of promoting the recognition and treatment of age-related sarcopenia in the clinical setting. Geriatr Gerontol Int 2012; 12: 388396.

引用

页码：388 / 396

页数：9

共 90 条

[1] Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells [J].

Artaza, JN ;

Bhasin, S ;

Magee, TR ;

Reisz-Porszasz, S ;

Shen, RQ ;

Groome, NP ;

Fareez, MM ;

Gonzalez-Cadavid, NF .

ENDOCRINOLOGY, 2005, 146 (08) :3547-3557

[2] Epidemiology of sarcopenia among the elderly in New Mexico [J].

Baumgartner, RN ;

Koehler, KM ;

Gallagher, D ;

Romero, L ;

Heymsfield, SB ;

Ross, RR ;

Garry, PJ ;

Lindeman, RD .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (08) :755-763

[3] PHYSIOLOGICAL HYPERINSULINEMIA STIMULATES PROTEIN-SYNTHESIS AND ENHANCES TRANSPORT OF SELECTED AMINO-ACIDS IN HUMAN SKELETAL-MUSCLE [J].

BIOLO, G ;

FLEMING, RYD ;

WOLFE, RR .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) :811-819

[4] Interventions for sarcopenia and muscle weakness in older people [J].

Borst, SE .

AGE AND AGEING, 2004, 33 (06) :548-555

[5] Vitamin D Deficiency/Insufficiency Practice Patterns in a Veterans Health Administration Long-Term Care Population: A Retrospective Analysis [J].

Braddy, Kathryn K. ;

Imam, Syed N. ;

Palla, Kavita R. ;

Lee, Todd A. .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2009, 10 (09) :653-657

[6] Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle [J].

Buford, Thomas W. ;

Cooke, Matthew B. ;

Willoughby, Darryn S. .

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2009, 107 (04) :463-471

[7] Short-term effects of leptin on skeletal muscle protein metabolism in the rat [J].

Carbó, N ;

Ribas, V ;

Busquets, S ;

Alvarez, B ;

López-Soriano, FJ ;

Argilés, JM .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2000, 11 (09) :431-435

[8]

Centers for Disease Control and Prevention (CDC), 2003, MMWR Morb Mortal Wkly Rep, V52, P101

[9] Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function [J].

Chow, Lisa S. ;

Greenlund, Laura J. ;

Asmann, Yan W. ;

Short, Kevin R. ;

McCrady, Shelly K. ;

Levine, James A. ;

Nair, K. Sreekumaran .

JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (03) :1078-1089

[10] Special article "Green Banana" -: Sarcopenia ≠ dynapenia [J].

Clark, Brian C. ;

Manini, Todd M. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2008, 63 (08) :829-834

← 1 2 3 4 5 6 7 8 9 →