Quercetin and ovarian cancer: An evaluation based on a systematic review

Background: Some studies have suggested chemopreventive and therapeutic effects of quercetin (Q) on carcinogenesis. The aim of this review was to evaluate the association between Q and ovarian cancer risk and induced sensitivity to some types of chemotherapeutic drugs among human researches and antiproliferative effects of this flavonoid in the animals and cell lines. Materials and Methods: Data for this systematic review were achieved through searches of the MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Cochrane, SID, and Magiran databases for studies published up to May 2015. Relevant studies were reviewed based on Preferred Reporting Item for Systematic Review and Meta-analysis guidelines. Results: From the total number of 220 papers obtained at the initial search, 13 publications including 1 prospective, 2 case-control, 1 animal, and 9 in vitro human and animal cancer cell lines studies were eligible. Conclusion: Despite findings in laboratory settings, results from the epidemiological studies commented that the potentially protective effects of Q not be able to significantly decrease ovarian cancer risk at levels commonly consumed (1.01-31.7 mg/day) in a typical diet. Also, animal and in vitro studies suggest that Q exerts anticancer effects via inhibiting tumor growth, and angiogenesis, interrupt the cell cycle, and induce apoptosis. It is highlighted the need for more studies to be conducted.