Toward a stable hydroxyphosphorane

被引：11

作者：

Hanes, RE

Lynch, VM

Anslyn, EV ^{[1
]}

Dalby, KN

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

[2] Univ Texas, Coll Pharm, Div Med Chem, Austin, TX 78712 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 02期

关键词：

D O I：

10.1021/ol016941d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Hydroxy-pentaoxy-phosphoranes are transient intermediates formed during the hydrolysis of various phosphoesters. Kinetic analyses support the existence of such compounds, although they are not isolated. In an attempt to create a stable example, 2 equiv of a ligand possessing a very high effective molarity were attached to a central phosphorus. Instead of obtaining a hydroxyphosphorane, analysis by P-31 and F-19 NMR spectroscopy and X-ray crystallography showed the product to be a phosphotriester. The reason for this is discussed.

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页码：201 / 203

页数：3

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