Thiotepa-busulfan-fludarabine as a conditioning regimen for patients with myelofibrosis undergoing allogeneic hematopoietic transplantation: a single center experience

被引:10
作者
Memoli, Mara [1 ,2 ]
Paviglianiti, Annalisa [1 ]
Malard, Florent [1 ,3 ,4 ]
Battipaglia, Giorgia [1 ,4 ]
Brissot, Eolia [1 ,3 ,4 ]
Mediavilla, Clemence [1 ,4 ]
Bianchessi, Antonio [1 ,5 ]
Banet, Anne [1 ]
Van de Wyngaert, Zoe [1 ]
Ledraa, Tounes [1 ]
Belhocine, Ramdane [1 ]
Sestili, Simona [1 ]
Lapusan, Simona [1 ]
Hirsch, Pierre [3 ,4 ,6 ]
Favale, Fabrizia [3 ,4 ,6 ]
Boussaroque, Agathe [3 ,4 ,6 ]
Bonnin, Agnes [1 ]
Vekhoff, Anne [1 ]
Legrand, Ollivier [1 ,3 ,4 ]
Mohty, Mohamad [1 ,3 ,4 ]
Dulery, Remy [1 ,3 ,4 ]
机构
[1] St Antoine Hosp, AP HP, Dept Hematol & Cellular Therapy, 184 Rue Faubourg St Antoine, F-75012 Paris, France
[2] Univ Naples Federico II, Hematol & Hematopoiet Stem Cell Transplant Ctr, Dept Med & Surg, Naples, Italy
[3] INSERM, UMRs 938, Paris, France
[4] Sorbonne Univ, Hop St Antoine, AP HP, Paris, France
[5] Univ Pavia, Dept Mol Med, Pavia, Italy
[6] Hop St Antoine, AP HP, Serv Hematol Biol, Paris, France
关键词
Thiotepa; busulfan; fludarabine; HSCT; TBF; myelofibrosis; STEM-CELL TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; LEUKEMIA WORKING PARTY; HAPLOIDENTICAL TRANSPLANTATION; EUROPEAN-SOCIETY; RISK-FACTORS; MARROW; SPLENECTOMY; RUXOLITINIB; MANAGEMENT;
D O I
10.1080/10428194.2020.1827246
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We assessed the outcomes associated with thiotepa, busulfan and fludarabine (TBF) conditioning regimen in a cohort of 29 consecutive patients allografted for myelofibrosis (MF). The median age was 56 (range 42-70) years. According to the refined Dynamic International Prognostic Scoring System (DIPSS-plus), 15 (52%) patients were classified as high risk. Graft source was peripheral blood stem cells in 27 patients. Donor type was HLA-matched related (n = 5), matched unrelated (n = 16), mismatched unrelated (n = 1), and haploidentical (n = 7). All but 2 patients engrafted. The cumulative incidence (CI) of grade II-IV acute graft-versus-host disease (GVHD) was 21% (95% CI, 10-42) at day 100. The CI of chronic GVHD was 39% (95% CI, 23-65) at 3 years. The median follow-up period was 39 (range 14-60) months. Overall survival was 69% (95% CI, 50-83) at 3 years. No relapse was observed. TBF is a valid conditioning strategy in patients with MF.
引用
收藏
页码:419 / 427
页数:9
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