Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities

被引：58

作者：

Kumar, Atul ^{[1
]}

Ahmad, Pervez ^{[1
]}

Maurya, Ram Awatar ^{[1
]}

Singh, A. B. ^{[2
]}

Srivastava, Arvind K. ^{[2
]}

机构：

[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 01期

关键词：

2-Aryl-naphtho[1,2-d]oxazole; Protein tyrosine phoshatase-1B inhibitors; Antidiabetic activity; Lipid and triglyceride lowering activity; TYROSINE-PHOSPHATASE; 1B;

D O I：

10.1016/j.ejmech.2008.03.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-aryl-naphtho[1,2-d]oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity. The compounds have been screened in vivo for antidiabetic activity under sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) and db/db mice model. Compounds 8 and 12 have shown promising PTP-1B inhibitory activity, significant antidiabetic activity, moderate lipid and triglyceride lowering activity. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：109 / 116

页数：8

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